Eicosanoids: Lipid mediators of inflammation in transplantation

Paulo N. Rocha, Troy J. Plumb, Thomas M. Coffman

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Eicosanoids are a family of lipid mediators derived from the metabolism of arachidonic acid. Eicosanoids, such as prostanoids and leukotrienes, have a wide range of biological actions including potent effects on inflammation and immunity. It has been almost 20 years since the first reports emerged suggesting a role for eicosanoids in transplantation. Since then, a number of functions have been ascribed to these mediators, ranging from immunomodulation to regulation of allograft hemodynamics. In this review, we will highlight the effects of eicosanoids in transplantation, focusing particularly on evidence provided by gene targeting studies. In the future, pharmacological manipulation of eicosanoids and their receptors may provide a novel approach for controlling inflammation and promoting allograft acceptance.

Original languageEnglish (US)
Pages (from-to)215-227
Number of pages13
JournalSpringer Seminars in Immunopathology
Volume25
Issue number2
DOIs
StatePublished - Sep 1 2003

Fingerprint

Inflammation Mediators
Eicosanoids
Transplantation
Lipids
Eicosanoid Receptors
Allografts
Inflammation
Immunomodulation
Gene Targeting
Leukotrienes
Arachidonic Acid
Prostaglandins
Immunity
Hemodynamics
Pharmacology

ASJC Scopus subject areas

  • Immunology

Cite this

Eicosanoids : Lipid mediators of inflammation in transplantation. / Rocha, Paulo N.; Plumb, Troy J.; Coffman, Thomas M.

In: Springer Seminars in Immunopathology, Vol. 25, No. 2, 01.09.2003, p. 215-227.

Research output: Contribution to journalReview article

Rocha, Paulo N. ; Plumb, Troy J. ; Coffman, Thomas M. / Eicosanoids : Lipid mediators of inflammation in transplantation. In: Springer Seminars in Immunopathology. 2003 ; Vol. 25, No. 2. pp. 215-227.
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