Efficient synthesis of tricyclic benzobisoxazines by silica gel catalysis

Gaëlle Spagnol, Andrzej Rajca, Suchada Rajca

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Abstract

A new method for the synthesis of tricyclic benzobisoxazines, based upon silica gel-catalyzed formation of two 3,1-oxazine rings, is reported. The reversibility of the condensation reaction, forming an oxazine ring, allows for implementation of silica gel catalyzed ketone exchange in benzobisoxazine, thus enabling access to nonsymmetric derivatives of benzobisoxazines.

Original languageEnglish (US)
Pages (from-to)1867-1869
Number of pages3
JournalJournal of Organic Chemistry
Volume72
Issue number5
DOIs
StatePublished - Mar 2 2007

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ASJC Scopus subject areas

  • Organic Chemistry

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