Efficacy of sub-antimicrobial dose doxycycline in post-menopausal women: Clinical outcomes

Richard A Reinhardt, Julie A. Stoner, Lorne M. Golub, Mark S. Wolff, His Ming Lee, Trudy A. Meinberg, James C. Lynch, Maria E. Ryan, Timo Sorsa, Jeffrey B Payne

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Aims: To determine the clinical efficacy of a 2-year continuous sub-antimicrobial dose doxycycline (SDD; 20 mg bid) in post-menopausal, osteopenic, oestrogen-deficient women on periodontal maintenance. Materials and Methods: One-hundred and twenty-eight subjects were randomized to SDD (n=64) or placebo (n=64). Clinical measurements were performed at posterior interproximal sites at baseline and every 6 months during this 2-year randomized, double-blind, placebo-controlled clinical trial with adjunctive, no-cost 3-4-month periodontal maintenance. Statistical analyses of secondary outcomes from this clinical trial used Generalized Estimating Equations in primarily intent-to-treat analyses. Results: For the placebo group, 3.4% of the sites showed improvement in clinical attachment levels (CAL) and 2.7% had progressive loss in CAL; for the SDD group, 5.0% of the sites showed an improvement in CAL and 2.2% had progressive loss in CAL. This difference (2.1% of sites) was more favourable in the SDD group than in the placebo [odds ratio (OR)=0.81%, 95% confidence interval (CI): 0.67-0.97, p=0.03] in these well-maintained patients, whereas probing depths, bleeding on probing and supragingival plaque did not differ significantly between groups (p>0.2). However, in exploratory subgroup analysis of non-smokers, SDD showed reduced bleeding versus placebo (27% versus 33%; p=0.05). In protocol-adherent subjects, the odds of bleeding were 34% lower for SDD (p=0.05). Conclusions: Analyses of secondary outcomes of this clinical trial indicated that SDD may be of benefit in reducing progressive attachment loss in post-menopausal females; additional research is needed to confirm these findings. Protocol registered at ClinicalTrials.gov. Identifier:NCT00066027

Original languageEnglish (US)
Pages (from-to)768-775
Number of pages8
JournalJournal of Clinical Periodontology
Volume34
Issue number9
DOIs
StatePublished - Sep 2007

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Doxycycline
Placebos
Hemorrhage
Maintenance
Clinical Trials
Controlled Clinical Trials
Estrogens
Odds Ratio
Confidence Intervals
Costs and Cost Analysis
Research

Keywords

  • Osteopenia
  • Periodontal maintenance
  • Periodontitis
  • Post-menopausal
  • Randomized clinical trial
  • Relative clinical attachment
  • Sub-antimicrobial dose doxycycline

ASJC Scopus subject areas

  • Periodontics

Cite this

Efficacy of sub-antimicrobial dose doxycycline in post-menopausal women : Clinical outcomes. / Reinhardt, Richard A; Stoner, Julie A.; Golub, Lorne M.; Wolff, Mark S.; Lee, His Ming; Meinberg, Trudy A.; Lynch, James C.; Ryan, Maria E.; Sorsa, Timo; Payne, Jeffrey B.

In: Journal of Clinical Periodontology, Vol. 34, No. 9, 09.2007, p. 768-775.

Research output: Contribution to journalArticle

Reinhardt, Richard A ; Stoner, Julie A. ; Golub, Lorne M. ; Wolff, Mark S. ; Lee, His Ming ; Meinberg, Trudy A. ; Lynch, James C. ; Ryan, Maria E. ; Sorsa, Timo ; Payne, Jeffrey B. / Efficacy of sub-antimicrobial dose doxycycline in post-menopausal women : Clinical outcomes. In: Journal of Clinical Periodontology. 2007 ; Vol. 34, No. 9. pp. 768-775.
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AU - Wolff, Mark S.

AU - Lee, His Ming

AU - Meinberg, Trudy A.

AU - Lynch, James C.

AU - Ryan, Maria E.

AU - Sorsa, Timo

AU - Payne, Jeffrey B

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