Efficacy of liposome-encapsulated ciprofloxacin compared with ciprofloxacin and ceftriaxone in rat model of pneumococcal pneumonia

Martin H. Ellbogen, Keith M. Olsen, Martha J. Gentry-Nielsen, Laurel C. Preheim

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Encapsulation of ciprofloxacin in sterically stabilized liposomes results in a prolonged circulation time and improved pharmacokinetics. Liposome-encapsulated ciprofloxacin was compared with conventional ciprofloxacin and ceftriaxone in a rat model of pneumococcal pneumonia. Male Sprague-Dawley rats were infected transtracheally with type 3 Streptococcus pneumoniae and then treated with intravenous ceftriaxone (100 mg/kg), ciprofloxacin (40 or 80 mg/kg) or liposomal ciprofloxacin (40 or 80 mg/kg) administered once or twice daily for 3 days. White blood counts, development of bacteraemia and mortality were measured for 10 days. Antibiotic concentrations in serum, lung lavage fluid and white blood cells recovered from lung lavage fluid were determined. Liposomal ciprofloxacin concentrations were significantly higher in serum and lavage fluid compared with conventional ciprofloxacin, resulting in greater area under the serum concentration-time curve and maximum serum concentration. Despite these higher concentrations, survival rates were similar between groups treated with equivalent doses of liposomal ciprofloxacin versus ciprofloxacin. When antibiotics were given once daily, ceftriaxone was more effective than either form of ciprofloxacin.

Original languageEnglish (US)
Pages (from-to)83-91
Number of pages9
JournalJournal of Antimicrobial Chemotherapy
Volume51
Issue number1
DOIs
StatePublished - Jan 1 2003

Fingerprint

Pneumococcal Pneumonia
Ceftriaxone
Ciprofloxacin
Liposomes
Bronchoalveolar Lavage Fluid
Serum
Anti-Bacterial Agents
Therapeutic Irrigation
Bacteremia
Streptococcus pneumoniae
Sprague Dawley Rats
Leukocytes
Survival Rate
Pharmacokinetics

Keywords

  • Experimental pneumococcal pneumonia
  • Liposomal ciprofloxacin
  • Rat model of pnemococcal pneumonia
  • Rat pneumonia model

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Efficacy of liposome-encapsulated ciprofloxacin compared with ciprofloxacin and ceftriaxone in rat model of pneumococcal pneumonia. / Ellbogen, Martin H.; Olsen, Keith M.; Gentry-Nielsen, Martha J.; Preheim, Laurel C.

In: Journal of Antimicrobial Chemotherapy, Vol. 51, No. 1, 01.01.2003, p. 83-91.

Research output: Contribution to journalArticle

Ellbogen, Martin H. ; Olsen, Keith M. ; Gentry-Nielsen, Martha J. ; Preheim, Laurel C. / Efficacy of liposome-encapsulated ciprofloxacin compared with ciprofloxacin and ceftriaxone in rat model of pneumococcal pneumonia. In: Journal of Antimicrobial Chemotherapy. 2003 ; Vol. 51, No. 1. pp. 83-91.
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