Efficacy of dose regimen and observation of herd immunity from a vaccine against Escherichia coli O157:H7 for feedlot cattle

R. E. Peterson, T. J. Klopfenstein, R. A. Moxley, G. E. Erickson, S. Hinkley, D. Rogan, D. R. Smith

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A clinical trial was conducted to test the effect of a vaccine product containing type III secreted proteins of Escherichia coli O157:H7 on the probability that feedlot steers shed E. coli O157:H7 in feces. Six hundred eight same-source steers were utilized. Of these, 480 steers were assigned randomly to 60 pens (eight head per pen) and to one of four vaccination treatments (120 cattle per treatment, two head per treatment per pen). The four treatments were (i) no vaccination; (ii) one dose, vaccinated once at reimplant (day 42); (iii) two doses, vaccinated on arrival (day 0) and again at reimplant (day 42); and (iv) three doses, vaccinated on arrival (day 0), on day 21, and again at reimplant (day 42). The remaining 128 steers were assigned randomly to 12 pens within the same feedlot to serve as unvaccinated external controls. The probability of detecting E. coli O157:H7 among cattle receiving different doses of vaccine was compared with that of unvaccinated external control cattle, accounting for clustering by repeated measures, block, and pen and fixed effects of vaccine, corn product, and test period. Vaccine efficacy of receiving one, two, and three doses of vaccine was 68, 66, and 73%, respectively, compared with cattle in pens not receiving vaccine. Cattle receiving three doses of vaccine were significantly less likely to shed E. coli O157:H7 than unvaccinated cattle within the same pen. Unvaccinated cattle housed with vaccinated cattle were 59% less likely to shed E. coli O157:H7 than cattle in pens not receiving vaccine, likely because they benefited from herd immunity. This study supports the hypothesis that vaccination with this vaccine product effectively reduces the probability for cattle to shed E. coli O157:H7. There was no indication that the vaccine affected performance or carcass quality. In addition, we found that vaccinating a majority of cattle within a pen offered a significant protective effect (herd immunity) to unvaccinated cattle within the same pen.

Original languageEnglish (US)
Pages (from-to)2561-2567
Number of pages7
JournalJournal of food protection
Volume70
Issue number11
DOIs
StatePublished - Nov 2007

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Herd Immunity
Escherichia coli O157
feedlots
Vaccines
Observation
vaccines
cattle
dosage
Vaccination
vaccination
herd immunity
Head
corn products
carcass quality
Therapeutics
Feces
Zea mays
protective effect

ASJC Scopus subject areas

  • Food Science
  • Microbiology

Cite this

Efficacy of dose regimen and observation of herd immunity from a vaccine against Escherichia coli O157:H7 for feedlot cattle. / Peterson, R. E.; Klopfenstein, T. J.; Moxley, R. A.; Erickson, G. E.; Hinkley, S.; Rogan, D.; Smith, D. R.

In: Journal of food protection, Vol. 70, No. 11, 11.2007, p. 2561-2567.

Research output: Contribution to journalArticle

Peterson, R. E. ; Klopfenstein, T. J. ; Moxley, R. A. ; Erickson, G. E. ; Hinkley, S. ; Rogan, D. ; Smith, D. R. / Efficacy of dose regimen and observation of herd immunity from a vaccine against Escherichia coli O157:H7 for feedlot cattle. In: Journal of food protection. 2007 ; Vol. 70, No. 11. pp. 2561-2567.
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