Efficacy of a combination viral vaccine for protection of cattle against experimental infection with field isolates of bovine herpesvirus-1

John A. Ellis, Sheryl E. Gow, Noriko Goji, Clinton J Jones, Aspen Workman, Gail Henderson, Carrie Rhodes, Glenn Alaniz, Todd R. Meinert, Cassius M. Tucker

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective-To determine whether a combination viral vaccine containing a modified-live bovine herpesvirus-1 (BHV-1) would protect calves from infection with virulent field strains of BHV-1 for weeks or months after vaccination Design-Randomized controlled trial, performed in 2 replicates. Animals-63 weaned 4- to 6-month-old crossbred beef calves seronegative for antibody against BHV-1. Procedures-Calves were randomly allocated to 1 of 2 treatment groups. Control calves (n = 10/replicate) received a combination modified-live mixed viral vaccine without BHV-1 and treatment calves (20 and 23/replicate) received a combination modified-live mixed viral vaccine containing BHV-1. Each group was challenged via aerosol with 1 of 2 field strains of BHV-1, 30 days after vaccination in replicate 1 and 97 days after vaccination in replicate 2. After challenge, calves were commingled in 1 drylot pen. Clinical signs, immune responses, and nasal shedding of virus were monitored for 10 days after challenge, after which the calves were euthanatized and tracheal lesions were assessed. Results-Vaccination stimulated production of BHV-1-specific IgG antibody that cross-neutralized several field and laboratory strains of BHV-1. Challenge with both field strains of BHV-1 resulted in moderate to severe respiratory tract disease in control calves. Treatment calves had significantly fewer signs of clinical disease, shed less BHV-1, had less or no weight loss after challenge, and had fewer tracheal lesions than control calves for at least 97 days after vaccination. Conclusions and Clinical Relevance-Administration of the combination modified-live BHV-1 vaccine yielded significant disease-sparing effects in calves experimentally infected with virulent field strains of BHV-1.

Original languageEnglish (US)
Pages (from-to)563-572
Number of pages10
JournalJournal of the American Veterinary Medical Association
Volume235
Issue number5
DOIs
StatePublished - Sep 1 2009

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Viral Vaccines
Bovine Herpesvirus 1
Combined Vaccines
Bovine herpesvirus 1
calves
cattle
Infection
infection
Vaccination
vaccination
lesions (animal)
viral vaccines
Herpesvirus Vaccines
Virus Shedding
Respiratory Tract Diseases
antibodies
viral shedding
Antibodies
aerosols
Aerosols

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Efficacy of a combination viral vaccine for protection of cattle against experimental infection with field isolates of bovine herpesvirus-1. / Ellis, John A.; Gow, Sheryl E.; Goji, Noriko; Jones, Clinton J; Workman, Aspen; Henderson, Gail; Rhodes, Carrie; Alaniz, Glenn; Meinert, Todd R.; Tucker, Cassius M.

In: Journal of the American Veterinary Medical Association, Vol. 235, No. 5, 01.09.2009, p. 563-572.

Research output: Contribution to journalArticle

Ellis, JA, Gow, SE, Goji, N, Jones, CJ, Workman, A, Henderson, G, Rhodes, C, Alaniz, G, Meinert, TR & Tucker, CM 2009, 'Efficacy of a combination viral vaccine for protection of cattle against experimental infection with field isolates of bovine herpesvirus-1', Journal of the American Veterinary Medical Association, vol. 235, no. 5, pp. 563-572. https://doi.org/10.2460/javma.235.5.563
Ellis, John A. ; Gow, Sheryl E. ; Goji, Noriko ; Jones, Clinton J ; Workman, Aspen ; Henderson, Gail ; Rhodes, Carrie ; Alaniz, Glenn ; Meinert, Todd R. ; Tucker, Cassius M. / Efficacy of a combination viral vaccine for protection of cattle against experimental infection with field isolates of bovine herpesvirus-1. In: Journal of the American Veterinary Medical Association. 2009 ; Vol. 235, No. 5. pp. 563-572.
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