Efficacy and side effects of albendazole currently in use against Ascaris, Trichuris and hookworm among school children in Wondo Genet, southern Ethiopia

Fikreslasie Samuel, Abraham Degarege, Berhanu Erko

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Monitoring the efficacy of anthelminthic drugs is essential. The objective of this study was to assess the efficacy of a single oral dose of 400. mg albendazole (ABZ) against the major soil-transmitted helminth (STH) infection in school children, Wondo Genet, southern Ethiopia. A single fresh stool sample was collected from 298 school children and examined using a duplicate smear of the Kato-Katz method. Children positive for STH infections were treated with single oral dose of 400. mg ABZ and re-examined for intestinal helminth infections 21. days post-treatment. The participants were interviewed for symptoms related with the drug uptake 24. h after ABZ treatment. Children positive for Schistosoma mansoni infections were treated with Praziquantel (40. mg/kg of body weight) after an ABZ treatment follow up survey. 51.3%, 49.7%, 44.6% and 88.3% had hookworm, Ascaris lumbricoides, Trichuris trichiura and any intestinal helminth infection, respectively. Cure rates were 97.4% for hookworm, 96.6% for A. lumbricoides and 30.8% for T. trichiura infections. Egg reduction rates (ERRs) were 99.8% for hookworm, 99.9% for A. lumbricoides and 83.1% for T. trichiura infections. Mild and transient symptoms were observed among the participants which were quite frequent. In conclusion, a 400. mg single oral dose of ABZ was effective against hookworm and A. lumbricoides but less efficacious against T. trichiura infection. The drug resulted in high ERRs for hookworm, A. lumbricoides and T. trichiura. Administration of the drug in repeated doses or in combination with other drugs might be necessary.

Original languageEnglish (US)
Pages (from-to)450-455
Number of pages6
JournalParasitology International
Volume63
Issue number2
DOIs
StatePublished - Apr 1 2014

Fingerprint

Ascaris
Trichuris
Viverridae
Ancylostomatoidea
Albendazole
Ethiopia
Ascaris lumbricoides
Helminths
Infection
Pharmaceutical Preparations
Ovum
Soil
Essential Drugs
Praziquantel
Schistosomiasis mansoni
Therapeutics
Body Weight

Keywords

  • Albendazole
  • Cure rate
  • Efficacy
  • Egg reduction rate
  • Helminths

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Efficacy and side effects of albendazole currently in use against Ascaris, Trichuris and hookworm among school children in Wondo Genet, southern Ethiopia. / Samuel, Fikreslasie; Degarege, Abraham; Erko, Berhanu.

In: Parasitology International, Vol. 63, No. 2, 01.04.2014, p. 450-455.

Research output: Contribution to journalArticle

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abstract = "Monitoring the efficacy of anthelminthic drugs is essential. The objective of this study was to assess the efficacy of a single oral dose of 400. mg albendazole (ABZ) against the major soil-transmitted helminth (STH) infection in school children, Wondo Genet, southern Ethiopia. A single fresh stool sample was collected from 298 school children and examined using a duplicate smear of the Kato-Katz method. Children positive for STH infections were treated with single oral dose of 400. mg ABZ and re-examined for intestinal helminth infections 21. days post-treatment. The participants were interviewed for symptoms related with the drug uptake 24. h after ABZ treatment. Children positive for Schistosoma mansoni infections were treated with Praziquantel (40. mg/kg of body weight) after an ABZ treatment follow up survey. 51.3{\%}, 49.7{\%}, 44.6{\%} and 88.3{\%} had hookworm, Ascaris lumbricoides, Trichuris trichiura and any intestinal helminth infection, respectively. Cure rates were 97.4{\%} for hookworm, 96.6{\%} for A. lumbricoides and 30.8{\%} for T. trichiura infections. Egg reduction rates (ERRs) were 99.8{\%} for hookworm, 99.9{\%} for A. lumbricoides and 83.1{\%} for T. trichiura infections. Mild and transient symptoms were observed among the participants which were quite frequent. In conclusion, a 400. mg single oral dose of ABZ was effective against hookworm and A. lumbricoides but less efficacious against T. trichiura infection. The drug resulted in high ERRs for hookworm, A. lumbricoides and T. trichiura. Administration of the drug in repeated doses or in combination with other drugs might be necessary.",
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