Efficacy and safety of blue-light scleral cross-linking

Hans Peter Iseli, Eberhard Spoerl, Peter Wiedemann, Ronald R Krueger, Theo Seiler

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

PURPOSE: To evaluate the efficacy of blue-light scleral cross-linking as well as its safety in preventing retinal damage beneath the treated sclera. METHODS: Six rabbits were unilaterally treated with topical riboflavin (0.5%) and blue light (465 nm) on the equatorial sclera using a light emitting diode source with an exposure area of 9 mm in diameter. Four weeks after the treatment, the animals were euthanized and the exposed sclera and contralateral eye sclera excised for comparative testing of biomechanical rigidity and histologic retinal cellular damage. Extensiometry was performed to evaluate the stress-strain curve of treated versus untreated sclera, and light microscopy of the treated sclera and underlying retina were also comparatively evaluated. RESULTS: Blue-light scleral cross-linking showed a three-fold increased stiffening in all tested animals in the stress-strain curve. Histological investigation revealed no retinal damage in any of the treated eyes. CONCLUSIONS: Scleral cross-linking with riboflavin and blue light (465 nm) has a stiffening effect on the sclera without histological tissue damage to the retina.

Original languageEnglish (US)
JournalJournal of Refractive Surgery
Volume24
Issue number7
StatePublished - Sep 1 2008

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Sclera
Safety
Light
Riboflavin
Retina
Microscopy
Rabbits

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Iseli, H. P., Spoerl, E., Wiedemann, P., Krueger, R. R., & Seiler, T. (2008). Efficacy and safety of blue-light scleral cross-linking. Journal of Refractive Surgery, 24(7).

Efficacy and safety of blue-light scleral cross-linking. / Iseli, Hans Peter; Spoerl, Eberhard; Wiedemann, Peter; Krueger, Ronald R; Seiler, Theo.

In: Journal of Refractive Surgery, Vol. 24, No. 7, 01.09.2008.

Research output: Contribution to journalArticle

Iseli, HP, Spoerl, E, Wiedemann, P, Krueger, RR & Seiler, T 2008, 'Efficacy and safety of blue-light scleral cross-linking', Journal of Refractive Surgery, vol. 24, no. 7.
Iseli HP, Spoerl E, Wiedemann P, Krueger RR, Seiler T. Efficacy and safety of blue-light scleral cross-linking. Journal of Refractive Surgery. 2008 Sep 1;24(7).
Iseli, Hans Peter ; Spoerl, Eberhard ; Wiedemann, Peter ; Krueger, Ronald R ; Seiler, Theo. / Efficacy and safety of blue-light scleral cross-linking. In: Journal of Refractive Surgery. 2008 ; Vol. 24, No. 7.
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