Effects of volume expansion with fluosol-DA on renal function of the nonhuman primate

William H. Roccaforte, Charles R. Wesley, Joseph P. Gilmore

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The renal responses to an intravenous infusion of a high O<inf>2</inf> affinity fluorocarbon equal to 15% of the estimated blood volume was determined in 5 monkeys and 1 baboon. In response to the infusion, blood pressure, renal plasma flow and glomerular filtration rate did not change significantly while heart rate and central venous pressure increased transiently. Significant increases in sodium and potassium excretion and osmolal and free-water clearances occurred. The renal responses to Fluosol-DA (20%) mimic in general those observed when blood volume is expanded with isotonic isooncotic dextran solutions.

Original languageEnglish (US)
Pages (from-to)293-298
Number of pages6
JournalKidney and Blood Pressure Research
Volume7
Issue number5
DOIs
StatePublished - 1984

Fingerprint

Blood Volume
Primates
Renal Plasma Flow
Kidney
Fluorocarbons
Central Venous Pressure
Papio
Dextrans
Glomerular Filtration Rate
Intravenous Infusions
Haplorhini
Potassium
Heart Rate
Sodium
Blood Pressure
Water
glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination

Keywords

  • Fluorocarbons
  • Renal function
  • Volume expansion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Nephrology

Cite this

Effects of volume expansion with fluosol-DA on renal function of the nonhuman primate. / Roccaforte, William H.; Wesley, Charles R.; Gilmore, Joseph P.

In: Kidney and Blood Pressure Research, Vol. 7, No. 5, 1984, p. 293-298.

Research output: Contribution to journalArticle

Roccaforte, William H. ; Wesley, Charles R. ; Gilmore, Joseph P. / Effects of volume expansion with fluosol-DA on renal function of the nonhuman primate. In: Kidney and Blood Pressure Research. 1984 ; Vol. 7, No. 5. pp. 293-298.
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