Effects of volume expansion with fluosol-DA on renal function of the nonhuman primate

William H. Roccaforte, Charles R. Wesley, Joseph P. Gilmore

Research output: Contribution to journalArticle

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Abstract

The renal responses to an intravenous infusion of a high O2 affinity fluorocarbon equal to 15% of the estimated blood volume was determined in 5 monkeys and 1 baboon. In response to the infusion, blood pressure, renal plasma flow and glomerular filtration rate did not change significantly while heart rate and central venous pressure increased transiently. Significant increases in sodium and potassium excretion and osmolal and free-water clearances occurred. The renal responses to Fluosol-DA (20%) mimic in general those observed when blood volume is expanded with isotonic isooncotic dextran solutions.

Original languageEnglish (US)
Pages (from-to)293-298
Number of pages6
JournalKidney and Blood Pressure Research
Volume7
Issue number5
DOIs
Publication statusPublished - Jan 1 1984

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Keywords

  • Fluorocarbons
  • Renal function
  • Volume expansion

ASJC Scopus subject areas

  • Nephrology
  • Cardiology and Cardiovascular Medicine

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