Effects of the anti-migraine drug sumatriptan on muscle energy metabolism: Relationship to side-effects

M. D. Boska, K. M.A. Welch, L. Schultz, J. Nelson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Sumatriptan succinate (Imitrex) is a 5-HT(5-hydroxytryptamine) agonist used for relief of migraine symptoms. Some individuals experience short-lived side-effects, including heaviness of the limbs, chest heaviness and muscle aches and pains. The effects of this drug on skeletal muscle energy metabolism were studied during short submaximal isometric exercises. We studied ATP flux from anaerobic glycolysis (An Gly), the creatine kinase reaction (CK) and oxidative phosphorylation (Ox Phos) using 31P nuclear magnetic resonance spectroscopy (31P MRS) kinetic data collected during exercise. It was found that side-effects induced acutely by injection of 6 mg sumatriptan succinate s.c. were associated with reduced oxygen storage in peripheral skeletal muscle 5-20 min after injection as demonstrated by a transient reduction in mitochondrial function at end-exercise. These results suggest that mild vasoconstriction in peripheral skeletal muscle is associated with the action of sumatriptan and is likely to be the source of the side-effects experienced by some users. Migraine with aura patients were more susceptible to this effect than migraine without aura patients.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalCephalalgia
Volume20
Issue number1
DOIs
StatePublished - Dec 1 2000

Fingerprint

Sumatriptan
Migraine Disorders
Energy Metabolism
Skeletal Muscle
Exercise
Muscles
Pharmaceutical Preparations
Migraine without Aura
Migraine with Aura
Serotonin Receptor Agonists
Injections
Myalgia
Oxidative Phosphorylation
Glycolysis
Creatine Kinase
Vasoconstriction
Magnetic Resonance Spectroscopy
Thorax
Extremities
Adenosine Triphosphate

Keywords

  • Energy metabolism
  • Exercise
  • P MRS
  • Sumatriptan succinate

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Effects of the anti-migraine drug sumatriptan on muscle energy metabolism : Relationship to side-effects. / Boska, M. D.; Welch, K. M.A.; Schultz, L.; Nelson, J.

In: Cephalalgia, Vol. 20, No. 1, 01.12.2000, p. 39-44.

Research output: Contribution to journalArticle

Boska, M. D. ; Welch, K. M.A. ; Schultz, L. ; Nelson, J. / Effects of the anti-migraine drug sumatriptan on muscle energy metabolism : Relationship to side-effects. In: Cephalalgia. 2000 ; Vol. 20, No. 1. pp. 39-44.
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