Effects of temperature and elevated intracranial pressure on peripheral and brain stem auditory responses in dogs

Timothy A Jones, W. J. Weidner

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Far-field recordings of central (P2 through P4) and peripheral (cochlear microphonic; and compound action potential of the eighth nerve) auditory responses were used to assess changes in auditory function resulting from elevated intracranial pressure. Normative data for eight dogs were obtained. The relationship between response latency and core temperature was examined. A mean slope of -0.17 ms/°C resulted for the temperature range of 35.0 to 40.0°C. Systemic arterial pressure was measured in order to identify the cerebral ischemic response. Responses were not altered significantly unless the intracranial pressure approached within 15 to 30 mm Hg of mean systemic arterial pressure. Changes in the response consisted of both enhancement and deterioration during intracranial pressure elevation and were accompanied by increases in systemic arterial pressure during that elevation. Supernormal amplitudes of the action potential also occurred during recovery periods. Results suggest that: (i) during elevated intracranial pressure, changes in both central and peripheral auditory function result from ischemia rather than pressure-induced distortion of the cochlea or central neural assemblies. (ii) Far-field auditory responses may include an O2-dependent cochlear microphonic. (iii) An unknown process causing enhancement of central and peripheral neural responses exists and operates in connection with intracranial hypertension. Possible mechanisms underlying enhancement of response components are discussed.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalExperimental Neurology
Volume92
Issue number1
DOIs
StatePublished - Jan 1 1986

Fingerprint

Intracranial Hypertension
Brain Stem Auditory Evoked Potentials
Cochlea
Dogs
Arterial Pressure
Temperature
Action Potentials
Cochlear Nerve
Intracranial Pressure
Reaction Time
Ischemia
Pressure

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

Effects of temperature and elevated intracranial pressure on peripheral and brain stem auditory responses in dogs. / Jones, Timothy A; Weidner, W. J.

In: Experimental Neurology, Vol. 92, No. 1, 01.01.1986, p. 1-12.

Research output: Contribution to journalArticle

@article{b33c3e2e118c4d96bd8ff32df533add2,
title = "Effects of temperature and elevated intracranial pressure on peripheral and brain stem auditory responses in dogs",
abstract = "Far-field recordings of central (P2 through P4) and peripheral (cochlear microphonic; and compound action potential of the eighth nerve) auditory responses were used to assess changes in auditory function resulting from elevated intracranial pressure. Normative data for eight dogs were obtained. The relationship between response latency and core temperature was examined. A mean slope of -0.17 ms/°C resulted for the temperature range of 35.0 to 40.0°C. Systemic arterial pressure was measured in order to identify the cerebral ischemic response. Responses were not altered significantly unless the intracranial pressure approached within 15 to 30 mm Hg of mean systemic arterial pressure. Changes in the response consisted of both enhancement and deterioration during intracranial pressure elevation and were accompanied by increases in systemic arterial pressure during that elevation. Supernormal amplitudes of the action potential also occurred during recovery periods. Results suggest that: (i) during elevated intracranial pressure, changes in both central and peripheral auditory function result from ischemia rather than pressure-induced distortion of the cochlea or central neural assemblies. (ii) Far-field auditory responses may include an O2-dependent cochlear microphonic. (iii) An unknown process causing enhancement of central and peripheral neural responses exists and operates in connection with intracranial hypertension. Possible mechanisms underlying enhancement of response components are discussed.",
author = "Jones, {Timothy A} and Weidner, {W. J.}",
year = "1986",
month = "1",
day = "1",
doi = "10.1016/0014-4886(86)90120-2",
language = "English (US)",
volume = "92",
pages = "1--12",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Effects of temperature and elevated intracranial pressure on peripheral and brain stem auditory responses in dogs

AU - Jones, Timothy A

AU - Weidner, W. J.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - Far-field recordings of central (P2 through P4) and peripheral (cochlear microphonic; and compound action potential of the eighth nerve) auditory responses were used to assess changes in auditory function resulting from elevated intracranial pressure. Normative data for eight dogs were obtained. The relationship between response latency and core temperature was examined. A mean slope of -0.17 ms/°C resulted for the temperature range of 35.0 to 40.0°C. Systemic arterial pressure was measured in order to identify the cerebral ischemic response. Responses were not altered significantly unless the intracranial pressure approached within 15 to 30 mm Hg of mean systemic arterial pressure. Changes in the response consisted of both enhancement and deterioration during intracranial pressure elevation and were accompanied by increases in systemic arterial pressure during that elevation. Supernormal amplitudes of the action potential also occurred during recovery periods. Results suggest that: (i) during elevated intracranial pressure, changes in both central and peripheral auditory function result from ischemia rather than pressure-induced distortion of the cochlea or central neural assemblies. (ii) Far-field auditory responses may include an O2-dependent cochlear microphonic. (iii) An unknown process causing enhancement of central and peripheral neural responses exists and operates in connection with intracranial hypertension. Possible mechanisms underlying enhancement of response components are discussed.

AB - Far-field recordings of central (P2 through P4) and peripheral (cochlear microphonic; and compound action potential of the eighth nerve) auditory responses were used to assess changes in auditory function resulting from elevated intracranial pressure. Normative data for eight dogs were obtained. The relationship between response latency and core temperature was examined. A mean slope of -0.17 ms/°C resulted for the temperature range of 35.0 to 40.0°C. Systemic arterial pressure was measured in order to identify the cerebral ischemic response. Responses were not altered significantly unless the intracranial pressure approached within 15 to 30 mm Hg of mean systemic arterial pressure. Changes in the response consisted of both enhancement and deterioration during intracranial pressure elevation and were accompanied by increases in systemic arterial pressure during that elevation. Supernormal amplitudes of the action potential also occurred during recovery periods. Results suggest that: (i) during elevated intracranial pressure, changes in both central and peripheral auditory function result from ischemia rather than pressure-induced distortion of the cochlea or central neural assemblies. (ii) Far-field auditory responses may include an O2-dependent cochlear microphonic. (iii) An unknown process causing enhancement of central and peripheral neural responses exists and operates in connection with intracranial hypertension. Possible mechanisms underlying enhancement of response components are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0022581007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022581007&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(86)90120-2

DO - 10.1016/0014-4886(86)90120-2

M3 - Article

VL - 92

SP - 1

EP - 12

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 1

ER -