Effects of systemic and topical nicotine on pulpal blood flow in dogs

William T. Johnson, Georgia K. Johnson, Gordon L. Todd, Yiu K. Fung

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Abstract It has been suggested that nicotine exerts cardiovascular effects which are similar to stimulation of the sympatho‐adrenal system. If this observation is true, nicotine administration would decrease pulpal blood flow and possibly alter the pulpal response to injury. The purpose of this study was to measure pulpal blood flow in dogs using the radiolabelled microsphere method following topical or systemic administration of nicotine for 28 days. Thirteen dogs were divided into three groups. Group one received topical nicotine (8 mg nicotine/kg/day) combined with orabase which was applied in two equal doses to the mandibular anterior gingiva. Group two received systemic nicotine (2.5 mg/kg/day) delivered by osmotic pumps implanted subcutaneously in the back of each animals' neck. Group three were controls, and these animals received either topical orabase twice daily applied to the mandibular anterior gingiva or saline via osmotic pumps. Results indicated pulpal blood flow increased from Day 0 to Day 28 in both nicotine treated groups. Group one (topical nicotine) exhibited a mean increase in blood flow of 21.8 ml/min/100 g. while group two exhibited a mean increase of 50.1 ml/min/100 g. Group three, the control animals, exhibited a mean decrease in pulpal blood flow of 22.1 ml/min/100 g over the 28‐day interval. These changes were not statistically significant (p > 0.05).

Original languageEnglish (US)
Pages (from-to)71-74
Number of pages4
JournalDental Traumatology
Volume9
Issue number2
DOIs
StatePublished - Apr 1993

Fingerprint

Nicotine
Dogs
Gingiva
Microspheres
Neck
Control Groups
Wounds and Injuries

Keywords

  • blood flow
  • nicotine
  • pulp

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Effects of systemic and topical nicotine on pulpal blood flow in dogs. / Johnson, William T.; Johnson, Georgia K.; Todd, Gordon L.; Fung, Yiu K.

In: Dental Traumatology, Vol. 9, No. 2, 04.1993, p. 71-74.

Research output: Contribution to journalArticle

Johnson, William T. ; Johnson, Georgia K. ; Todd, Gordon L. ; Fung, Yiu K. / Effects of systemic and topical nicotine on pulpal blood flow in dogs. In: Dental Traumatology. 1993 ; Vol. 9, No. 2. pp. 71-74.
@article{91bf34855c7c4272b3a6988ab9fa31e0,
title = "Effects of systemic and topical nicotine on pulpal blood flow in dogs",
abstract = "Abstract It has been suggested that nicotine exerts cardiovascular effects which are similar to stimulation of the sympatho‐adrenal system. If this observation is true, nicotine administration would decrease pulpal blood flow and possibly alter the pulpal response to injury. The purpose of this study was to measure pulpal blood flow in dogs using the radiolabelled microsphere method following topical or systemic administration of nicotine for 28 days. Thirteen dogs were divided into three groups. Group one received topical nicotine (8 mg nicotine/kg/day) combined with orabase which was applied in two equal doses to the mandibular anterior gingiva. Group two received systemic nicotine (2.5 mg/kg/day) delivered by osmotic pumps implanted subcutaneously in the back of each animals' neck. Group three were controls, and these animals received either topical orabase twice daily applied to the mandibular anterior gingiva or saline via osmotic pumps. Results indicated pulpal blood flow increased from Day 0 to Day 28 in both nicotine treated groups. Group one (topical nicotine) exhibited a mean increase in blood flow of 21.8 ml/min/100 g. while group two exhibited a mean increase of 50.1 ml/min/100 g. Group three, the control animals, exhibited a mean decrease in pulpal blood flow of 22.1 ml/min/100 g over the 28‐day interval. These changes were not statistically significant (p > 0.05).",
keywords = "blood flow, nicotine, pulp",
author = "Johnson, {William T.} and Johnson, {Georgia K.} and Todd, {Gordon L.} and Fung, {Yiu K.}",
year = "1993",
month = "4",
doi = "10.1111/j.1600-9657.1993.tb00663.x",
language = "English (US)",
volume = "9",
pages = "71--74",
journal = "Dental Traumatology",
issn = "1600-4469",
publisher = "Blackwell Munksgaard",
number = "2",

}

TY - JOUR

T1 - Effects of systemic and topical nicotine on pulpal blood flow in dogs

AU - Johnson, William T.

AU - Johnson, Georgia K.

AU - Todd, Gordon L.

AU - Fung, Yiu K.

PY - 1993/4

Y1 - 1993/4

N2 - Abstract It has been suggested that nicotine exerts cardiovascular effects which are similar to stimulation of the sympatho‐adrenal system. If this observation is true, nicotine administration would decrease pulpal blood flow and possibly alter the pulpal response to injury. The purpose of this study was to measure pulpal blood flow in dogs using the radiolabelled microsphere method following topical or systemic administration of nicotine for 28 days. Thirteen dogs were divided into three groups. Group one received topical nicotine (8 mg nicotine/kg/day) combined with orabase which was applied in two equal doses to the mandibular anterior gingiva. Group two received systemic nicotine (2.5 mg/kg/day) delivered by osmotic pumps implanted subcutaneously in the back of each animals' neck. Group three were controls, and these animals received either topical orabase twice daily applied to the mandibular anterior gingiva or saline via osmotic pumps. Results indicated pulpal blood flow increased from Day 0 to Day 28 in both nicotine treated groups. Group one (topical nicotine) exhibited a mean increase in blood flow of 21.8 ml/min/100 g. while group two exhibited a mean increase of 50.1 ml/min/100 g. Group three, the control animals, exhibited a mean decrease in pulpal blood flow of 22.1 ml/min/100 g over the 28‐day interval. These changes were not statistically significant (p > 0.05).

AB - Abstract It has been suggested that nicotine exerts cardiovascular effects which are similar to stimulation of the sympatho‐adrenal system. If this observation is true, nicotine administration would decrease pulpal blood flow and possibly alter the pulpal response to injury. The purpose of this study was to measure pulpal blood flow in dogs using the radiolabelled microsphere method following topical or systemic administration of nicotine for 28 days. Thirteen dogs were divided into three groups. Group one received topical nicotine (8 mg nicotine/kg/day) combined with orabase which was applied in two equal doses to the mandibular anterior gingiva. Group two received systemic nicotine (2.5 mg/kg/day) delivered by osmotic pumps implanted subcutaneously in the back of each animals' neck. Group three were controls, and these animals received either topical orabase twice daily applied to the mandibular anterior gingiva or saline via osmotic pumps. Results indicated pulpal blood flow increased from Day 0 to Day 28 in both nicotine treated groups. Group one (topical nicotine) exhibited a mean increase in blood flow of 21.8 ml/min/100 g. while group two exhibited a mean increase of 50.1 ml/min/100 g. Group three, the control animals, exhibited a mean decrease in pulpal blood flow of 22.1 ml/min/100 g over the 28‐day interval. These changes were not statistically significant (p > 0.05).

KW - blood flow

KW - nicotine

KW - pulp

UR - http://www.scopus.com/inward/record.url?scp=0027582505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027582505&partnerID=8YFLogxK

U2 - 10.1111/j.1600-9657.1993.tb00663.x

DO - 10.1111/j.1600-9657.1993.tb00663.x

M3 - Article

C2 - 8404699

AN - SCOPUS:0027582505

VL - 9

SP - 71

EP - 74

JO - Dental Traumatology

JF - Dental Traumatology

SN - 1600-4469

IS - 2

ER -