Effects of Short-Term isolated zinc deficiency on intestinal growth and activities of several brush border enzymes in weanling rats

Jung H.Y. Park, Carter J. Grandjean, Dean Lowell Antonson, Jon A. Vanderhoof

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

To determine whether zinc has a specific role on intestinal growth and function, three groups of male weanling Sprague-Dawley rats were fed a semipurified zinc-deficient diet: ad libitum fed group received powdered diet and water containing 25 ppm of zinc; force fed (ZN, ZD) groups were fed identical amounts of diet to the ad libitum fed group by intragastric infusion three times per day. The diets were aqueous suspensions made with either deionized water (ZD) or water containing 25 ppm of zinc (ZN), and additional drinking water with (ZN) or without zinc (ZD) was offered ad libitum. Rats were sacrificed after 8 days of feeding. The ZD group showed growth arrest, perioral and periorbital dermal lesions, and abdominal distention within 8 days of feeding. Mucosal DNA, protein, sucrase, maltase, lactase, leucine aminopeptidase, and alkaline phosphatase were significantly decreased in the ZD group, whereas intestinal length, weight, and mucosal weight were unaltered. These results suggest that short-term isolated zinc deficiency impairs growth, digestion, and absorption in the rat small intestine, even in the absence of associated protein calorie malnutrition.

Original languageEnglish (US)
Pages (from-to)1333-1336
Number of pages4
JournalPediatric Research
Volume19
Issue number12
DOIs
StatePublished - Jan 1 1985

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Microvilli
Zinc
Enzymes
Growth
Diet
Water
Sucrase
Leucyl Aminopeptidase
Lactase
Weights and Measures
Protein-Energy Malnutrition
alpha-Glucosidases
Drinking Water
Small Intestine
Alkaline Phosphatase
Sprague Dawley Rats
Digestion
Suspensions
Skin
DNA

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Effects of Short-Term isolated zinc deficiency on intestinal growth and activities of several brush border enzymes in weanling rats. / Park, Jung H.Y.; Grandjean, Carter J.; Antonson, Dean Lowell; Vanderhoof, Jon A.

In: Pediatric Research, Vol. 19, No. 12, 01.01.1985, p. 1333-1336.

Research output: Contribution to journalArticle

Park, Jung H.Y. ; Grandjean, Carter J. ; Antonson, Dean Lowell ; Vanderhoof, Jon A. / Effects of Short-Term isolated zinc deficiency on intestinal growth and activities of several brush border enzymes in weanling rats. In: Pediatric Research. 1985 ; Vol. 19, No. 12. pp. 1333-1336.
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