Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma: A Review

Pooja Patel, Alon Harris, Carol Toris, Leslie Tobe, Matthew Lang, Aditya Belamkar, Adrienne Ng, Alice C. Verticchio Vercellin, Sunu Mathew, Brent Siesky

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Primary open-angle glaucoma (POAG) is a multifactorial optic neuropathy characterized by progressive retinal ganglion cell death and visual field loss. Some speculate that sex plays a role in the risk of developing POAG and that the physiological differences between men and women may be attributed to the variable effects of sex hormones on intraocular pressure, ocular blood flow, and/or neuroprotection. Estrogen, in the form of premenopausal status, pregnancy, and postmenopausal hormone therapy is associated with an increase in ocular blood flow, decrease in intraocular pressure and neuroprotective properties. The vasodilation caused by estrogen and its effects on aqueous humor outflow may contribute. In contrast, although testosterone may have known effects in the cardiovascular and cerebrovascular systems, there is no consensus as to its effects in ocular health or POAG. With a better understanding of sex hormones in POAG, sex hormone-derived preventative and therapeutic considerations in disease management may provide for improved sex-specific patient care.

Original languageEnglish (US)
Pages (from-to)1037-1041
Number of pages5
JournalJournal of Glaucoma
Volume27
Issue number12
DOIs
StatePublished - Dec 1 2018

Fingerprint

Gonadal Steroid Hormones
Intraocular Pressure
Blood Pressure
Estrogens
Optic Nerve Diseases
Retinal Ganglion Cells
Aqueous Humor
Disease Management
Cardiovascular System
Visual Fields
Vasodilation
Testosterone
Consensus
Patient Care
Cell Death
Hormones
Pregnancy
Primary Open Angle Glaucoma
Health
Therapeutics

Keywords

  • estrogen
  • glaucoma
  • intraocular pressure
  • neuroprotection
  • ocular blood flow
  • testosterone

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma : A Review. / Patel, Pooja; Harris, Alon; Toris, Carol; Tobe, Leslie; Lang, Matthew; Belamkar, Aditya; Ng, Adrienne; Verticchio Vercellin, Alice C.; Mathew, Sunu; Siesky, Brent.

In: Journal of Glaucoma, Vol. 27, No. 12, 01.12.2018, p. 1037-1041.

Research output: Contribution to journalReview article

Patel, P, Harris, A, Toris, C, Tobe, L, Lang, M, Belamkar, A, Ng, A, Verticchio Vercellin, AC, Mathew, S & Siesky, B 2018, 'Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma: A Review', Journal of Glaucoma, vol. 27, no. 12, pp. 1037-1041. https://doi.org/10.1097/IJG.0000000000001106
Patel, Pooja ; Harris, Alon ; Toris, Carol ; Tobe, Leslie ; Lang, Matthew ; Belamkar, Aditya ; Ng, Adrienne ; Verticchio Vercellin, Alice C. ; Mathew, Sunu ; Siesky, Brent. / Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma : A Review. In: Journal of Glaucoma. 2018 ; Vol. 27, No. 12. pp. 1037-1041.
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