Effects of salsalate therapy on recovery from vascular injury in female zucker fatty rats

Subramanyam N. Murthy, Cyrus V Desouza, Neal W. Bost, Rose Claire St. Hilaire, David B. Casey, Adeleke M. Badejo, Jasdeep S. Dhaliwal, Jennifer McGee, Dennis B. McNamara, Philip J. Kadowitz, Vivian A. Fonseca

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

OBJECTIVE - Salsalate is a dimeric form of salicylic acid that has been shown to have anti-inflammatory activity and to reduce glucose levels, insulin resistance, and cytokine expression. However, the effect of salsalate on vascular injury has not been determined. The objective of this study is to investigate the effect of salsalate on vascular injury and repair in a rat model of carotid artery balloon catheter injury. RESEARCH DESIGN AND METHODS - Salsalate treatment was started in female Zucker fatty rats (insulin resistant) 1 week before carotid artery balloon catheter injury and continued for 21 days, at which time the animals were killed and studied. RESULTS - Treatment with salsalate significantly decreased the intima-to-media ratio and upregulated the expression of aortic endothelial nitric oxide synthase (eNOS), phosphorylated eNOS (p-eNOS) (ser 1177), and manganese superoxide dismutase (MnSOD) and reduced serum interleukin (IL)-6 with concomitant downregulation of nuclear factor (NF) κB subunit p65 and vascular endothelial growth factor (VEGF) expression in the balloon-injured carotid artery of female Zucker fatty rats. CONCLUSIONS - The present study shows that salsalate treatment decreases vascular damage caused by balloon catheter injury in female Zucker fatty rats. The beneficial effect of salsalate on vascular injury was associated with upregulation of eNOS, p-eNOS, and MnSOD, which reduce oxidative stress and have anti-inflammatory properties, as evidenced by reduction in serum IL-6 and the downregulation of VEGF and NFκB, which promote inflammation without changing glucose levels. These results suggest that salsalate may be useful in reducing vascular injury and restenosis following interventional revascularization procedures.

Original languageEnglish (US)
Pages (from-to)3240-3246
Number of pages7
JournalDiabetes
Volume59
Issue number12
DOIs
StatePublished - Dec 1 2010

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Vascular System Injuries
Insulin
Nitric Oxide Synthase Type III
Carotid Arteries
Catheters
Therapeutics
Vascular Endothelial Growth Factor A
Superoxide Dismutase
Interleukin-6
Wounds and Injuries
Anti-Inflammatory Agents
Down-Regulation
Glucose
Salicylic Acid
salicylsalicylic acid
Serum
Blood Vessels
Insulin Resistance
Oxidative Stress
Research Design

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Murthy, S. N., Desouza, C. V., Bost, N. W., St. Hilaire, R. C., Casey, D. B., Badejo, A. M., ... Fonseca, V. A. (2010). Effects of salsalate therapy on recovery from vascular injury in female zucker fatty rats. Diabetes, 59(12), 3240-3246. https://doi.org/10.2337/db09-1761

Effects of salsalate therapy on recovery from vascular injury in female zucker fatty rats. / Murthy, Subramanyam N.; Desouza, Cyrus V; Bost, Neal W.; St. Hilaire, Rose Claire; Casey, David B.; Badejo, Adeleke M.; Dhaliwal, Jasdeep S.; McGee, Jennifer; McNamara, Dennis B.; Kadowitz, Philip J.; Fonseca, Vivian A.

In: Diabetes, Vol. 59, No. 12, 01.12.2010, p. 3240-3246.

Research output: Contribution to journalArticle

Murthy, SN, Desouza, CV, Bost, NW, St. Hilaire, RC, Casey, DB, Badejo, AM, Dhaliwal, JS, McGee, J, McNamara, DB, Kadowitz, PJ & Fonseca, VA 2010, 'Effects of salsalate therapy on recovery from vascular injury in female zucker fatty rats', Diabetes, vol. 59, no. 12, pp. 3240-3246. https://doi.org/10.2337/db09-1761
Murthy SN, Desouza CV, Bost NW, St. Hilaire RC, Casey DB, Badejo AM et al. Effects of salsalate therapy on recovery from vascular injury in female zucker fatty rats. Diabetes. 2010 Dec 1;59(12):3240-3246. https://doi.org/10.2337/db09-1761
Murthy, Subramanyam N. ; Desouza, Cyrus V ; Bost, Neal W. ; St. Hilaire, Rose Claire ; Casey, David B. ; Badejo, Adeleke M. ; Dhaliwal, Jasdeep S. ; McGee, Jennifer ; McNamara, Dennis B. ; Kadowitz, Philip J. ; Fonseca, Vivian A. / Effects of salsalate therapy on recovery from vascular injury in female zucker fatty rats. In: Diabetes. 2010 ; Vol. 59, No. 12. pp. 3240-3246.
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AU - Casey, David B.

AU - Badejo, Adeleke M.

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AU - McNamara, Dennis B.

AU - Kadowitz, Philip J.

AU - Fonseca, Vivian A.

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