Effects of reduced food intake on morphometry and cell production in the small intestine of the rat

Helen L. Lipscomb, John G Sharp

Research output: Contribution to journalArticle

Abstract

The present study examined the effects of a 60% reduction in food intake on kinetic and morphometric parameters in the small intestine of adult male Lewis rats. We observed that, after 20 days, the wet weight of jejunum and ileum, thickness of muscularis externa of duodenum, crypt depth throughout the intestine, and DPM/mg and DPM/crypt in ileum were decreased in animals on reduced food intake when compared to their paired, normally fed controls. These results demonstrated that reduced food intake caused distinctive effects focused primarily in the ileum, thus opening to question the use of the technique of pair feeding as a control for studies of intestinal cell proliferation in which manipulations of the animals result in altered food intake or body weight.

Original languageEnglish (US)
Pages (from-to)285-292
Number of pages8
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Volume42
Issue number1
DOIs
StatePublished - Dec 1 1983

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Small Intestine
Eating
Ileum
Jejunum
Duodenum
Intestines
Body Weight
Cell Proliferation
Weights and Measures

Keywords

  • Food Deprivation
  • Growth
  • Rats
  • Small Intestine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Effects of reduced food intake on morphometry and cell production in the small intestine of the rat. / Lipscomb, Helen L.; Sharp, John G.

In: Virchows Archiv B Cell Pathology Including Molecular Pathology, Vol. 42, No. 1, 01.12.1983, p. 285-292.

Research output: Contribution to journalArticle

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