Effects of phenobarbital administration on levels of physiological antioxidants in rat liver

H. K J Hahn, A. J. Barak, D. J. Tuma, Michael Floyd Sorrell

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Administration of phenobarbital to rats over a period of 5 days was shown to increase hepatic lipid peroxidation concomitant with induction of cytochrome P-450 and cytochrome c reductase. The purpose of this study was to determine whether the increase in lipid peroxidation was due to a lowering in hepatic antioxidants. The results show that increased lipid peroxidation was not due to a decreased level of antioxidants since the fat-soluble antioxidants were unchanged and ascorbate, a water-soluble antioxidant, was elevated. The relationship of the increase in hepatic ascorbate to enhanced lipid peroxidation is discussed.

Original languageEnglish (US)
Pages (from-to)341-344
Number of pages4
JournalPharmacology
Volume17
Issue number6
DOIs
StatePublished - Jan 1 1978

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Phenobarbital
Lipid Peroxidation
Antioxidants
Liver
Cytochrome Reductases
Cytochromes c
Cytochrome P-450 Enzyme System
Fats
Water

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of phenobarbital administration on levels of physiological antioxidants in rat liver. / Hahn, H. K J; Barak, A. J.; Tuma, D. J.; Sorrell, Michael Floyd.

In: Pharmacology, Vol. 17, No. 6, 01.01.1978, p. 341-344.

Research output: Contribution to journalArticle

Hahn, H. K J ; Barak, A. J. ; Tuma, D. J. ; Sorrell, Michael Floyd. / Effects of phenobarbital administration on levels of physiological antioxidants in rat liver. In: Pharmacology. 1978 ; Vol. 17, No. 6. pp. 341-344.
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