Effects of phenobarbital administration on levels of physiological antioxidants in rat liver

H. K J Hahn, A. J. Barak, D. J. Tuma, Michael Floyd Sorrell

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Administration of phenobarbital to rats over a period of 5 days was shown to increase hepatic lipid peroxidation concomitant with induction of cytochrome P-450 and cytochrome c reductase. The purpose of this study was to determine whether the increase in lipid peroxidation was due to a lowering in hepatic antioxidants. The results show that increased lipid peroxidation was not due to a decreased level of antioxidants since the fat-soluble antioxidants were unchanged and ascorbate, a water-soluble antioxidant, was elevated. The relationship of the increase in hepatic ascorbate to enhanced lipid peroxidation is discussed.

Original languageEnglish (US)
Pages (from-to)341-344
Number of pages4
Issue number6
Publication statusPublished - Jan 1 1978


ASJC Scopus subject areas

  • Pharmacology

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