Effects of N6-cyclopentyladenosine on afterdepolarizations and triggered activity induced by isoproterenol in guinea pig papillary muscle

Yulong Li, R. R. He

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: To investigate the effects of N6-cyclopentyladenosine (CPA, selective adenosine A1 receptor agonist) on afterdepolarizations and triggered activity induced by isoproterenol (Iso) in guinea pig papillary muscle. Methods: The stable and reproducible early afterdepolarization (EAD) and delayed afterdepolarization (DAD) of guinea pig papillary muscle were induced by Iso 50 nmol · L-1. The parameters of EAD and DAD were recorded using intracellular microelectrodes. Results: CPA markedly attenuated the development of EAD, DAD, and triggered activity (TA) induced by Iso in guinea pig papillary muscle. The inhibitory effects of CPA on Iso-induced EAD and DAD were antagonized by 8-phenyltheophylline (8-PT) and glibenclamide (Gli). Conclusion: ATP-sensitive K+ channels were involved in Iso-induced EAD and DAD, and in the inhibitory effects of CPA on EAD and DAD.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalActa Pharmacologica Sinica
Volume16
Issue number2
StatePublished - Mar 23 1995

Fingerprint

Papillary Muscles
Isoproterenol
Muscle
Guinea Pigs
Adenosine A1 Receptor Agonists
Glyburide
Microelectrodes
Adenosine Triphosphate
N(6)-cyclopentyladenosine

Keywords

  • adenosine
  • catecholamines
  • electrophysiology
  • glyburide
  • papillary muscles
  • theophylline

ASJC Scopus subject areas

  • Chemistry(all)
  • Pharmacology
  • Medicine(all)

Cite this

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title = "Effects of N6-cyclopentyladenosine on afterdepolarizations and triggered activity induced by isoproterenol in guinea pig papillary muscle",
abstract = "Aim: To investigate the effects of N6-cyclopentyladenosine (CPA, selective adenosine A1 receptor agonist) on afterdepolarizations and triggered activity induced by isoproterenol (Iso) in guinea pig papillary muscle. Methods: The stable and reproducible early afterdepolarization (EAD) and delayed afterdepolarization (DAD) of guinea pig papillary muscle were induced by Iso 50 nmol · L-1. The parameters of EAD and DAD were recorded using intracellular microelectrodes. Results: CPA markedly attenuated the development of EAD, DAD, and triggered activity (TA) induced by Iso in guinea pig papillary muscle. The inhibitory effects of CPA on Iso-induced EAD and DAD were antagonized by 8-phenyltheophylline (8-PT) and glibenclamide (Gli). Conclusion: ATP-sensitive K+ channels were involved in Iso-induced EAD and DAD, and in the inhibitory effects of CPA on EAD and DAD.",
keywords = "adenosine, catecholamines, electrophysiology, glyburide, papillary muscles, theophylline",
author = "Yulong Li and He, {R. R.}",
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T1 - Effects of N6-cyclopentyladenosine on afterdepolarizations and triggered activity induced by isoproterenol in guinea pig papillary muscle

AU - Li, Yulong

AU - He, R. R.

PY - 1995/3/23

Y1 - 1995/3/23

N2 - Aim: To investigate the effects of N6-cyclopentyladenosine (CPA, selective adenosine A1 receptor agonist) on afterdepolarizations and triggered activity induced by isoproterenol (Iso) in guinea pig papillary muscle. Methods: The stable and reproducible early afterdepolarization (EAD) and delayed afterdepolarization (DAD) of guinea pig papillary muscle were induced by Iso 50 nmol · L-1. The parameters of EAD and DAD were recorded using intracellular microelectrodes. Results: CPA markedly attenuated the development of EAD, DAD, and triggered activity (TA) induced by Iso in guinea pig papillary muscle. The inhibitory effects of CPA on Iso-induced EAD and DAD were antagonized by 8-phenyltheophylline (8-PT) and glibenclamide (Gli). Conclusion: ATP-sensitive K+ channels were involved in Iso-induced EAD and DAD, and in the inhibitory effects of CPA on EAD and DAD.

AB - Aim: To investigate the effects of N6-cyclopentyladenosine (CPA, selective adenosine A1 receptor agonist) on afterdepolarizations and triggered activity induced by isoproterenol (Iso) in guinea pig papillary muscle. Methods: The stable and reproducible early afterdepolarization (EAD) and delayed afterdepolarization (DAD) of guinea pig papillary muscle were induced by Iso 50 nmol · L-1. The parameters of EAD and DAD were recorded using intracellular microelectrodes. Results: CPA markedly attenuated the development of EAD, DAD, and triggered activity (TA) induced by Iso in guinea pig papillary muscle. The inhibitory effects of CPA on Iso-induced EAD and DAD were antagonized by 8-phenyltheophylline (8-PT) and glibenclamide (Gli). Conclusion: ATP-sensitive K+ channels were involved in Iso-induced EAD and DAD, and in the inhibitory effects of CPA on EAD and DAD.

KW - adenosine

KW - catecholamines

KW - electrophysiology

KW - glyburide

KW - papillary muscles

KW - theophylline

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