Effects of Nicotinic Acid on Induction of Hepatic Drug Metabolizing Enzymes by Chronic Ethanol Administration

D. J. Tuma, M. F. Sorrell, J. A. Vanderhoof, A. J. Barak

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Abstract

The content of cytochrome P-450 and activities of aniline hydroxylase and glucose-6-phosphatase were determined in the livers of rats fed ethanol and nicotinic acid singly and in combination for 4 weeks. Similar determinations were conducted in livers from rats administered phenobarbital and nicotinic acid alone and in combination for 4 weeks. Both chronic ethanol feeding and phenobarbital administration increased the content of cytochrome P-450 and aniline hydroxylase activity. Glucose-6-phos-phatase activity was elevated by ethanol feeding but not by phenobarbital. Nicotinic acid treatment increased the content of cy-tochrome P-450 and aniline hydroxylation in the ethanol-treated but not in the control or phenobarbital-treated animals. Nicotinic acid did not influence the activity of glucose-6-phosphatase in either the ethanol- or phenobarbital-treated rats. The results of this study are consistent with the existence of a unique cytochrome P-450 which is induced by ethanol feeding, and the induction of this hemoprotein is further enhanced by the concomitant administration of nicotinic acid with ethanol.

Original languageEnglish (US)
Pages (from-to)67-70
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume155
Issue number1
DOIs
StatePublished - May 1977

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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