Effects of nicotine withdrawal on central dopaminergic systems

Eric Y Fung, Marian J. Schmid, Todd M. Anderson, Yuen Sum Lau

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The behavioral and neurochemical manifestations in rats 24 h following the cessation of 14-day nicotine administration were investigated. Animals were implanted subcutaneously with osmotic minipumps which continuously released either saline or nicotine (1.5 mg/kg/day or 3.0 mg/kg/ day) for 14 days. After the animals were withdrawn from nicotine for 24 h, we observed a significant decrease of locomotor activities and a reduction of dopamine contents in the striatum and nucleus accumbens. Nicotine withdrawal did not affect the body weight, food, or water consumption, and no deficit in the acquisition of a conditioned avoidance task was found in these animals. In addition, nicotine withdrawal did not alter the density or the binding affinity (K(d)) of ligands to D1 and D2 receptors in the striatum. Although nicotine withdrawal did not alter the density or binding affinity of ligands to D1 receptors in the nucleus accumbens, the maximum number of D2 receptor sites were reduced by nicotine treatment. These results offer possible neurochemical mechanisms for changes of locomotor activity which occurred in rats during nicotine abstinence.

Original languageEnglish (US)
Pages (from-to)635-640
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume53
Issue number3
DOIs
StatePublished - Jan 1 1996

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Nicotine
Animals
Nucleus Accumbens
Locomotion
Rats
Ligands
Body Water
Drinking
Dopamine
Body Weight
Food
Water

Keywords

  • Nicotine withdrawal
  • Nucleus accumbens
  • Striatum

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Effects of nicotine withdrawal on central dopaminergic systems. / Fung, Eric Y; Schmid, Marian J.; Anderson, Todd M.; Lau, Yuen Sum.

In: Pharmacology Biochemistry and Behavior, Vol. 53, No. 3, 01.01.1996, p. 635-640.

Research output: Contribution to journalArticle

Fung, Eric Y ; Schmid, Marian J. ; Anderson, Todd M. ; Lau, Yuen Sum. / Effects of nicotine withdrawal on central dopaminergic systems. In: Pharmacology Biochemistry and Behavior. 1996 ; Vol. 53, No. 3. pp. 635-640.
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