Effects of mustine hydrochloride on mouse haematopoietic and lymphoid tissues

John G Sharp, D. B. Thomas, Cecilie V. Briscoe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

During the first 4 days after the intravenous administration of a lethal dose (100 μg) of mustine hydrochloride to mice, there is a marked decrease in the weights of the lymph nodes, thymus and spleen and in the cellularity of the femoral bone marrow. In the subsequent 4 days, the cellularity of the bone marrow increases to values within the normal range while the weights of the lymph nodes, thymus and spleen remain exceedingly small. In this bone marrow regenerating after the injection of mustine hydrochloride, 94% of the recognisable haematopoietic cells are granulocytes at various stages of maturation.

Original languageEnglish (US)
Pages (from-to)304-313
Number of pages10
JournalChemotherapy
Volume18
Issue number5
DOIs
StatePublished - Jan 1 1973

Fingerprint

Mechlorethamine
Lymphoid Tissue
Bone Marrow
Thymus Gland
Spleen
Lymph Nodes
Weights and Measures
Thigh
Granulocytes
Intravenous Administration
Reference Values
Injections

Keywords

  • Bone marrow regeneration
  • Granulocytopoiesis
  • Mouse bone marrow
  • Nitrogen mustard

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Effects of mustine hydrochloride on mouse haematopoietic and lymphoid tissues. / Sharp, John G; Thomas, D. B.; Briscoe, Cecilie V.

In: Chemotherapy, Vol. 18, No. 5, 01.01.1973, p. 304-313.

Research output: Contribution to journalArticle

Sharp, John G ; Thomas, D. B. ; Briscoe, Cecilie V. / Effects of mustine hydrochloride on mouse haematopoietic and lymphoid tissues. In: Chemotherapy. 1973 ; Vol. 18, No. 5. pp. 304-313.
@article{5928a11b95514dbc84fe5db5b383a7f9,
title = "Effects of mustine hydrochloride on mouse haematopoietic and lymphoid tissues",
abstract = "During the first 4 days after the intravenous administration of a lethal dose (100 μg) of mustine hydrochloride to mice, there is a marked decrease in the weights of the lymph nodes, thymus and spleen and in the cellularity of the femoral bone marrow. In the subsequent 4 days, the cellularity of the bone marrow increases to values within the normal range while the weights of the lymph nodes, thymus and spleen remain exceedingly small. In this bone marrow regenerating after the injection of mustine hydrochloride, 94{\%} of the recognisable haematopoietic cells are granulocytes at various stages of maturation.",
keywords = "Bone marrow regeneration, Granulocytopoiesis, Mouse bone marrow, Nitrogen mustard",
author = "Sharp, {John G} and Thomas, {D. B.} and Briscoe, {Cecilie V.}",
year = "1973",
month = "1",
day = "1",
doi = "10.1159/000221275",
language = "English (US)",
volume = "18",
pages = "304--313",
journal = "Chemotherapy",
issn = "0009-3157",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - Effects of mustine hydrochloride on mouse haematopoietic and lymphoid tissues

AU - Sharp, John G

AU - Thomas, D. B.

AU - Briscoe, Cecilie V.

PY - 1973/1/1

Y1 - 1973/1/1

N2 - During the first 4 days after the intravenous administration of a lethal dose (100 μg) of mustine hydrochloride to mice, there is a marked decrease in the weights of the lymph nodes, thymus and spleen and in the cellularity of the femoral bone marrow. In the subsequent 4 days, the cellularity of the bone marrow increases to values within the normal range while the weights of the lymph nodes, thymus and spleen remain exceedingly small. In this bone marrow regenerating after the injection of mustine hydrochloride, 94% of the recognisable haematopoietic cells are granulocytes at various stages of maturation.

AB - During the first 4 days after the intravenous administration of a lethal dose (100 μg) of mustine hydrochloride to mice, there is a marked decrease in the weights of the lymph nodes, thymus and spleen and in the cellularity of the femoral bone marrow. In the subsequent 4 days, the cellularity of the bone marrow increases to values within the normal range while the weights of the lymph nodes, thymus and spleen remain exceedingly small. In this bone marrow regenerating after the injection of mustine hydrochloride, 94% of the recognisable haematopoietic cells are granulocytes at various stages of maturation.

KW - Bone marrow regeneration

KW - Granulocytopoiesis

KW - Mouse bone marrow

KW - Nitrogen mustard

UR - http://www.scopus.com/inward/record.url?scp=0015839101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015839101&partnerID=8YFLogxK

U2 - 10.1159/000221275

DO - 10.1159/000221275

M3 - Article

VL - 18

SP - 304

EP - 313

JO - Chemotherapy

JF - Chemotherapy

SN - 0009-3157

IS - 5

ER -