Effects of left ventricular receptor stimulation on coronary blood flow in conscious dogs

Irving H Zucker, K. G. Cornish, J. Hackley, K. Bliss

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The present study was undertaken to determine the effects of intracoronary administration of the veratrum alkaloid veratridine on coronary blood flow and resistance in conscious, chronically instrumented intact and sinoaortic denervated dogs. Ten dogs were instrumented with a Doppler flow probe on the left anterior descending coronary artery. A chronic catheter was placed in the left circumflex coronary artery and in the aorta and left atrium. A Konigsberg pressure cell was placed in the left ventricle, and pacing leads were attached to the left atrium and ventricle. While heart rate was kept constant, bolus intracoronary injections of veratridine (0.1-0.4 μg/kg) were administered in the unblocked state after β1-receptor blockade, after α-receptor blockade, and after cholinergic blockade. In the unblocked state, late diastolic coronary resistance fell by 34.7 ± 5.0%. The maximum response was achieved at a time when arterial pressure was not significantly different from control. After β1-blockade, coronary resistance fell by 29.1 ± 7.9%. After combined α- and β-blockade, coronary resistance fell by 25.4 ± 6.5% in response to veratridine. The addition of atropine completely blocked the decrease in coronary resistance, changing it by an average of -0.10 ± 2.5%. The responses in sinoaortic denervated dogs were similar to those in intact animals. The response was abolished by vagotomy. We conclude that cardiac receptor stimulation causes a reflex decrease in coronary resistance in the awake dog that is completely accountable by a cholinergic mechanism.

Original languageEnglish (US)
Pages (from-to)II-54-II-60
JournalCirculation Research
Volume61
Issue number5 II SUPPL.
StatePublished - Jan 1 1987

Fingerprint

Veratridine
Dogs
Heart Atria
Cholinergic Agents
Heart Ventricles
Coronary Vessels
Veratrum Alkaloids
Vagotomy
Atropine
Reflex
Aorta
Arterial Pressure
Catheters
Heart Rate
Pressure
Injections

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Zucker, I. H., Cornish, K. G., Hackley, J., & Bliss, K. (1987). Effects of left ventricular receptor stimulation on coronary blood flow in conscious dogs. Circulation Research, 61(5 II SUPPL.), II-54-II-60.

Effects of left ventricular receptor stimulation on coronary blood flow in conscious dogs. / Zucker, Irving H; Cornish, K. G.; Hackley, J.; Bliss, K.

In: Circulation Research, Vol. 61, No. 5 II SUPPL., 01.01.1987, p. II-54-II-60.

Research output: Contribution to journalArticle

Zucker, IH, Cornish, KG, Hackley, J & Bliss, K 1987, 'Effects of left ventricular receptor stimulation on coronary blood flow in conscious dogs', Circulation Research, vol. 61, no. 5 II SUPPL., pp. II-54-II-60.
Zucker, Irving H ; Cornish, K. G. ; Hackley, J. ; Bliss, K. / Effects of left ventricular receptor stimulation on coronary blood flow in conscious dogs. In: Circulation Research. 1987 ; Vol. 61, No. 5 II SUPPL. pp. II-54-II-60.
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