Effects of left atrial stretch in cardiac-denervated and intact conscious dogs

D. C. Fater, Harold D Schultz, W. D. Sundet

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We monitored cardiovascular and renal function in conscious dogs with surgically denervated hearts during two experimental procedures: 1) inflation of a ballon in the left atrium and 2) intravascular volume expansion. The results obtained were compared with results from identical experiments on sham-operated control dogs. Left atrial balloon inflation in the sham-operated dogs produced an increase in left atrial pressure, heart rate, urine flow, and sodium secretion; central venous pressure decreased. These changes were absent in the cardiac-denervated dogs. Infusion of 6% dextran in isotonic saline (16% of estimated blood volume) increased the heart rate significantly in the control dogs but not in the cardiac-denervated dogs; other hemodynamic measurements were comparable in the two groups. Urine flow and sodium excretion increased significantly in both the cardiac-denervated and control dogs; the responses did not differ significantly between the two groups. These experiments demonstrate that inflation of a balloon in the left atrium of a conscious dog elicits diuretic and natriuretic responses that are dependent on intact cardiac neural pathways, presumably specifically dependent on afferent neural impulses from left atrial receptors. On the other hand, an increase in circulating blood volume induced by the intravenous infusion of an isotonic, isoncotic solution elicits diuretic and natriuretic responses in the cardiac-denervated dog that are similar to the renal responses produced in a control dog. Thus, although cardiac receptors are capable of eliciting reflex changes in both hemodynamics and renal function, it is not clear what role they play in mediating the renal responses evoked by increases in blood volume.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume11
Issue number6
StatePublished - Jan 1 1982

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Dogs
Economic Inflation
Blood Volume
Kidney
Heart Atria
Diuretics
Heart Rate
Hemodynamics
Sodium
Urine
Isotonic Solutions
Neural Pathways
Central Venous Pressure
Atrial Pressure
Dextrans
Intravenous Infusions
Reflex

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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Effects of left atrial stretch in cardiac-denervated and intact conscious dogs. / Fater, D. C.; Schultz, Harold D; Sundet, W. D.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 11, No. 6, 01.01.1982.

Research output: Contribution to journalArticle

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