Effects of isolated zinc deficiency on the composition of skeletal muscle, liver and bone during growth in rats

J. H.Y. Park, C. J. Grandjean, Dean Lowell Antonson, J. A. Vanderhoof

Research output: Contribution to journalArticle

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Abstract

We investigated the effects of zinc deficiency on body composition by using intragastric force-feeding to obviate decreased food intake and altered eating patterns. Weanling male Sprague-Dawley rats were fed a purified zinc-deficient diet: the ad libitum-fed control group (AL; eight rats) was given powdered diet and water containing 25 ppm zinc; the zinc-replete group (ZN; nine rats) was force-fed a diet blended with water containing zinc in an amount of equal caloric intake to the AL group and allowed access to water containing zinc. The zinc intake of ZN rats was approximately twice that of AL rats based on water intake. The zinc-deficient group (ZD; 13 rats) was fed similarly to the ZN group except deionized water was used for diet preparation and drinking water. After 8 d, body and muscle weight were lower in the ZD group than in the ZN group. Femur weights were similar in the two groups. Serum, liver and femur zinc concentrations were 85, 22 and 42% lower, respectively, in the ZD group than in the ZN group. Serum glucose, relative liver weight, liver glycogen and liver lipids were higher, but muscle and liver DNA were lower in the ZD group than in control groups.

Original languageEnglish (US)
Pages (from-to)610-617
Number of pages8
JournalJournal of Nutrition
Volume116
Issue number4
DOIs
StatePublished - Jan 1 1986

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Bone Development
skeletal muscle
Zinc
Skeletal Muscle
zinc
bones
liver
Liver
rats
Diet
Water
femur
diet
water
Femur
Eating
forced feeding
Weights and Measures
Muscles
muscles

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effects of isolated zinc deficiency on the composition of skeletal muscle, liver and bone during growth in rats. / Park, J. H.Y.; Grandjean, C. J.; Antonson, Dean Lowell; Vanderhoof, J. A.

In: Journal of Nutrition, Vol. 116, No. 4, 01.01.1986, p. 610-617.

Research output: Contribution to journalArticle

Park, J. H.Y. ; Grandjean, C. J. ; Antonson, Dean Lowell ; Vanderhoof, J. A. / Effects of isolated zinc deficiency on the composition of skeletal muscle, liver and bone during growth in rats. In: Journal of Nutrition. 1986 ; Vol. 116, No. 4. pp. 610-617.
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