Effects of increasing FiO2 on venous saturation during cardiopulmonary bypass in the swine model

Jeffery D. Nichols, Alfred H. Stammers, Scott A. Kmiecik, Jun Li Liu, Ryan J. Kohtz, Nancy J. Mills, Craig M. Petterson, Hong Zheng

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Adequacy of perfusion during cardiopulmonary bypass (CPB) is dependent on nutrient delivery and waste removal from the tissue. A recent study showed that over 75% of cardiopulmonary bypass procedures are completed using continuous venous saturation (SvO2) monitoring. The purpose of this study was to determine the effect of changing FiO2 concentration on SvO2. A total of eight mixed gender 45-kg swine were placed on CPB under moderate hypothermic conditions. Animals were divided evenly into two groups: Experimental, where FiO2 was increased to 100% and blood flow decreased to an SvO2 level of prechange in FiO2, and Control, where the same condition was created except no change in blood flow. Variables measured include hemodynamic, blood gas, intramyocardial pH, and lactic acid concentrations. In the experimental group, percentage change of blood flow was decreased from baseline 28.4% ± 12.5% (p < .005) as well as percentage change of oxygen delivery 23.9% ± 14.7% (p < .005). Systemic venous saturation percentage change was increased in both the experimental 14.4% ± 6.8% (p < .05) and control 11.2% ± 7.1% (p < .05) groups. Jugular venous saturation percentage change was decreased in the experimental group 7.8% ± 6.34% (p < .02), but not in the control animals. Myocardial venous saturation percentage change decreased in the experimental group to 3.73% ± 8.34% (p < .004). Experimental manipulation, however, did not significantly change jugular lactic acid concentrations or intramyocardial pH values. In conclusion, these results suggest that decreased blood flow adjusting for increased SvO2 associated with high PaO2 did not result in significant reduction of adequacy of perfusion markers for organs studied.

Original languageEnglish (US)
Pages (from-to)118-124
Number of pages7
JournalJournal of Extra-Corporeal Technology
Volume34
Issue number2
StatePublished - Jun 1 2002

Fingerprint

Cardiopulmonary Bypass
Swine
Lactic Acid
Neck
Perfusion
Gases
Hemodynamics
Oxygen
Food

Keywords

  • Adequacy of perfusion
  • Oxygen content
  • Oxygen delivery
  • Venous saturation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Health Professions (miscellaneous)
  • Cardiology and Cardiovascular Medicine

Cite this

Nichols, J. D., Stammers, A. H., Kmiecik, S. A., Liu, J. L., Kohtz, R. J., Mills, N. J., ... Zheng, H. (2002). Effects of increasing FiO2 on venous saturation during cardiopulmonary bypass in the swine model. Journal of Extra-Corporeal Technology, 34(2), 118-124.

Effects of increasing FiO2 on venous saturation during cardiopulmonary bypass in the swine model. / Nichols, Jeffery D.; Stammers, Alfred H.; Kmiecik, Scott A.; Liu, Jun Li; Kohtz, Ryan J.; Mills, Nancy J.; Petterson, Craig M.; Zheng, Hong.

In: Journal of Extra-Corporeal Technology, Vol. 34, No. 2, 01.06.2002, p. 118-124.

Research output: Contribution to journalArticle

Nichols, JD, Stammers, AH, Kmiecik, SA, Liu, JL, Kohtz, RJ, Mills, NJ, Petterson, CM & Zheng, H 2002, 'Effects of increasing FiO2 on venous saturation during cardiopulmonary bypass in the swine model', Journal of Extra-Corporeal Technology, vol. 34, no. 2, pp. 118-124.
Nichols JD, Stammers AH, Kmiecik SA, Liu JL, Kohtz RJ, Mills NJ et al. Effects of increasing FiO2 on venous saturation during cardiopulmonary bypass in the swine model. Journal of Extra-Corporeal Technology. 2002 Jun 1;34(2):118-124.
Nichols, Jeffery D. ; Stammers, Alfred H. ; Kmiecik, Scott A. ; Liu, Jun Li ; Kohtz, Ryan J. ; Mills, Nancy J. ; Petterson, Craig M. ; Zheng, Hong. / Effects of increasing FiO2 on venous saturation during cardiopulmonary bypass in the swine model. In: Journal of Extra-Corporeal Technology. 2002 ; Vol. 34, No. 2. pp. 118-124.
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abstract = "Adequacy of perfusion during cardiopulmonary bypass (CPB) is dependent on nutrient delivery and waste removal from the tissue. A recent study showed that over 75{\%} of cardiopulmonary bypass procedures are completed using continuous venous saturation (SvO2) monitoring. The purpose of this study was to determine the effect of changing FiO2 concentration on SvO2. A total of eight mixed gender 45-kg swine were placed on CPB under moderate hypothermic conditions. Animals were divided evenly into two groups: Experimental, where FiO2 was increased to 100{\%} and blood flow decreased to an SvO2 level of prechange in FiO2, and Control, where the same condition was created except no change in blood flow. Variables measured include hemodynamic, blood gas, intramyocardial pH, and lactic acid concentrations. In the experimental group, percentage change of blood flow was decreased from baseline 28.4{\%} ± 12.5{\%} (p < .005) as well as percentage change of oxygen delivery 23.9{\%} ± 14.7{\%} (p < .005). Systemic venous saturation percentage change was increased in both the experimental 14.4{\%} ± 6.8{\%} (p < .05) and control 11.2{\%} ± 7.1{\%} (p < .05) groups. Jugular venous saturation percentage change was decreased in the experimental group 7.8{\%} ± 6.34{\%} (p < .02), but not in the control animals. Myocardial venous saturation percentage change decreased in the experimental group to 3.73{\%} ± 8.34{\%} (p < .004). Experimental manipulation, however, did not significantly change jugular lactic acid concentrations or intramyocardial pH values. In conclusion, these results suggest that decreased blood flow adjusting for increased SvO2 associated with high PaO2 did not result in significant reduction of adequacy of perfusion markers for organs studied.",
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