Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies

Theodora Mantso, George Goussetis, Rodrigo Franco-Cruz, Sotiris Botaitis, Aglaia Pappa, Mihalis Panayiotidis

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat induction and represents a concept that is far from new as it goes back to ancient times when heat was used for treating various diseases, including malignancies. Such therapeutic strategy has gained even more popularity (over the last few decades) since various studies have shed light into understanding hyperthermia's underlying molecular mechanism(s) of action. In general, hyperthermia is applied as complementary (adjuvant) means in therapeutic protocols combining chemotherapy and/or irradiation both of which can induce irreversible cellular DNA damage. Furthermore, according to a number of in vitro, in vivo and clinical studies, hyperthermia has been shown to enhance the beneficial effects of DNA targeting therapeutic strategies by interfering with DNA repair response cascades. Therefore, the continuously growing evidence supporting hyperthermia's beneficial role in cancer treatment can also encourage its application as a DNA repair mitigation strategy. In this review article, we aim to provide detailed information on how hyperthermia acts on DNA damage and repair pathways and thus potentially contributing to various adjuvant therapeutic protocols relevant to more efficient cancer treatment strategies.

Original languageEnglish (US)
Pages (from-to)96-105
Number of pages10
JournalSeminars in Cancer Biology
Volume37-38
DOIs
StatePublished - Jun 1 2016

Fingerprint

DNA Damage
Fever
Neoplasms
DNA Repair
Hot Temperature
Therapeutics
Drug Therapy
DNA

Keywords

  • Cancer therapeutics
  • Cancer treatment
  • DNA damage
  • DNA repair
  • Hyperthermia

ASJC Scopus subject areas

  • Cancer Research

Cite this

Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies. / Mantso, Theodora; Goussetis, George; Franco-Cruz, Rodrigo; Botaitis, Sotiris; Pappa, Aglaia; Panayiotidis, Mihalis.

In: Seminars in Cancer Biology, Vol. 37-38, 01.06.2016, p. 96-105.

Research output: Contribution to journalReview article

Mantso, Theodora ; Goussetis, George ; Franco-Cruz, Rodrigo ; Botaitis, Sotiris ; Pappa, Aglaia ; Panayiotidis, Mihalis. / Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies. In: Seminars in Cancer Biology. 2016 ; Vol. 37-38. pp. 96-105.
@article{9989d6bbf71c4b10a9abbdad1d8757f1,
title = "Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies",
abstract = "Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat induction and represents a concept that is far from new as it goes back to ancient times when heat was used for treating various diseases, including malignancies. Such therapeutic strategy has gained even more popularity (over the last few decades) since various studies have shed light into understanding hyperthermia's underlying molecular mechanism(s) of action. In general, hyperthermia is applied as complementary (adjuvant) means in therapeutic protocols combining chemotherapy and/or irradiation both of which can induce irreversible cellular DNA damage. Furthermore, according to a number of in vitro, in vivo and clinical studies, hyperthermia has been shown to enhance the beneficial effects of DNA targeting therapeutic strategies by interfering with DNA repair response cascades. Therefore, the continuously growing evidence supporting hyperthermia's beneficial role in cancer treatment can also encourage its application as a DNA repair mitigation strategy. In this review article, we aim to provide detailed information on how hyperthermia acts on DNA damage and repair pathways and thus potentially contributing to various adjuvant therapeutic protocols relevant to more efficient cancer treatment strategies.",
keywords = "Cancer therapeutics, Cancer treatment, DNA damage, DNA repair, Hyperthermia",
author = "Theodora Mantso and George Goussetis and Rodrigo Franco-Cruz and Sotiris Botaitis and Aglaia Pappa and Mihalis Panayiotidis",
year = "2016",
month = "6",
day = "1",
doi = "10.1016/j.semcancer.2016.03.004",
language = "English (US)",
volume = "37-38",
pages = "96--105",
journal = "Seminars in Cancer Biology",
issn = "1044-579X",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies

AU - Mantso, Theodora

AU - Goussetis, George

AU - Franco-Cruz, Rodrigo

AU - Botaitis, Sotiris

AU - Pappa, Aglaia

AU - Panayiotidis, Mihalis

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat induction and represents a concept that is far from new as it goes back to ancient times when heat was used for treating various diseases, including malignancies. Such therapeutic strategy has gained even more popularity (over the last few decades) since various studies have shed light into understanding hyperthermia's underlying molecular mechanism(s) of action. In general, hyperthermia is applied as complementary (adjuvant) means in therapeutic protocols combining chemotherapy and/or irradiation both of which can induce irreversible cellular DNA damage. Furthermore, according to a number of in vitro, in vivo and clinical studies, hyperthermia has been shown to enhance the beneficial effects of DNA targeting therapeutic strategies by interfering with DNA repair response cascades. Therefore, the continuously growing evidence supporting hyperthermia's beneficial role in cancer treatment can also encourage its application as a DNA repair mitigation strategy. In this review article, we aim to provide detailed information on how hyperthermia acts on DNA damage and repair pathways and thus potentially contributing to various adjuvant therapeutic protocols relevant to more efficient cancer treatment strategies.

AB - Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat induction and represents a concept that is far from new as it goes back to ancient times when heat was used for treating various diseases, including malignancies. Such therapeutic strategy has gained even more popularity (over the last few decades) since various studies have shed light into understanding hyperthermia's underlying molecular mechanism(s) of action. In general, hyperthermia is applied as complementary (adjuvant) means in therapeutic protocols combining chemotherapy and/or irradiation both of which can induce irreversible cellular DNA damage. Furthermore, according to a number of in vitro, in vivo and clinical studies, hyperthermia has been shown to enhance the beneficial effects of DNA targeting therapeutic strategies by interfering with DNA repair response cascades. Therefore, the continuously growing evidence supporting hyperthermia's beneficial role in cancer treatment can also encourage its application as a DNA repair mitigation strategy. In this review article, we aim to provide detailed information on how hyperthermia acts on DNA damage and repair pathways and thus potentially contributing to various adjuvant therapeutic protocols relevant to more efficient cancer treatment strategies.

KW - Cancer therapeutics

KW - Cancer treatment

KW - DNA damage

KW - DNA repair

KW - Hyperthermia

UR - http://www.scopus.com/inward/record.url?scp=84962361070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962361070&partnerID=8YFLogxK

U2 - 10.1016/j.semcancer.2016.03.004

DO - 10.1016/j.semcancer.2016.03.004

M3 - Review article

C2 - 27025900

AN - SCOPUS:84962361070

VL - 37-38

SP - 96

EP - 105

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

SN - 1044-579X

ER -