Effects of endothelin on electrophysiological and contractile activity of guinea pig papillary muscles

Z. Zhao, L. Yu-Long, H. Rui-Rong

Research output: Contribution to journalArticle

Abstract

Effects of endothelin on electrophysiological activity and contractility were examined in guinea pig papillary muscle using intracellular microelectrode and contractile tension recording technique. The results indicated that ET-1 prolonged APD, especially PPD and increased the contractile tension in a dose-dependent manner. The ET-induced effects were not influenced by K+ channel blocker TE(A), but inhibited by L-type Ca2+ channel blocker nifedipine, ET(A) receptor selective antagonist BQ-123 and atriopeptin III in a concentration-dependent manner. It is suggested that the changes in electrophysiological activity and the positive inotropic effect induced by ET-1 in guinea pig muscles are due to the elevation of intracellular calcium, which may be mediated by ETA receptor.

Original languageEnglish (US)
Pages (from-to)152-159
Number of pages8
JournalActa Physiologica Sinica
Volume49
Issue number2
StatePublished - Jul 10 1997

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Keywords

  • Atriopeptin III
  • BQ-123
  • Electrophysiology
  • Endothelin
  • Nifedipine
  • Papillary muscle
  • TEA

ASJC Scopus subject areas

  • Medicine(all)

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