Effects of Ciprofloxacin on the Humoral and Cellular Immune Responses in Balb/c-Mice

W. Roszkowski, H. L. Ko, K. Roszkowski, P. Ciborowski, J. Jeljaszewicz, G. Pulverer

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effects of a 7 days chemotherapy with ciprofloxacin on the humoral and cellular immune responses in Balb/c-mice were examined. Ciprofloxacin-doses used were calculated on a body weight basis from therapeutic dosages in humans. In a dose-dependent way IgM as well as IgG responses were significantly increased. The delayed-type hypersensitivity reaction to oxazolone was not significantly changed. In in vivo as well in vitro experiments ciprofloxacin showed no modulatory activity on the concanavalin A and LPS-induced proliferative activities of mouse spleen cells.

Original languageEnglish (US)
Pages (from-to)396-402
Number of pages7
JournalZentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
Volume262
Issue number3
DOIs
StatePublished - Jan 1 1986

Fingerprint

Ciprofloxacin
Humoral Immunity
Cellular Immunity
Oxazolone
Delayed Hypersensitivity
Concanavalin A
Immunoglobulin M
Spleen
Immunoglobulin G
Body Weight
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Effects of Ciprofloxacin on the Humoral and Cellular Immune Responses in Balb/c-Mice. / Roszkowski, W.; Ko, H. L.; Roszkowski, K.; Ciborowski, P.; Jeljaszewicz, J.; Pulverer, G.

In: Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A, Vol. 262, No. 3, 01.01.1986, p. 396-402.

Research output: Contribution to journalArticle

Roszkowski, W. ; Ko, H. L. ; Roszkowski, K. ; Ciborowski, P. ; Jeljaszewicz, J. ; Pulverer, G. / Effects of Ciprofloxacin on the Humoral and Cellular Immune Responses in Balb/c-Mice. In: Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A. 1986 ; Vol. 262, No. 3. pp. 396-402.
@article{e04acadd94a542b7a5c524b5379ef188,
title = "Effects of Ciprofloxacin on the Humoral and Cellular Immune Responses in Balb/c-Mice",
abstract = "The effects of a 7 days chemotherapy with ciprofloxacin on the humoral and cellular immune responses in Balb/c-mice were examined. Ciprofloxacin-doses used were calculated on a body weight basis from therapeutic dosages in humans. In a dose-dependent way IgM as well as IgG responses were significantly increased. The delayed-type hypersensitivity reaction to oxazolone was not significantly changed. In in vivo as well in vitro experiments ciprofloxacin showed no modulatory activity on the concanavalin A and LPS-induced proliferative activities of mouse spleen cells.",
author = "W. Roszkowski and Ko, {H. L.} and K. Roszkowski and P. Ciborowski and J. Jeljaszewicz and G. Pulverer",
year = "1986",
month = "1",
day = "1",
doi = "10.1016/S0176-6724(86)80013-X",
language = "English (US)",
volume = "262",
pages = "396--402",
journal = "International Journal of Medical Microbiology",
issn = "1438-4221",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
number = "3",

}

TY - JOUR

T1 - Effects of Ciprofloxacin on the Humoral and Cellular Immune Responses in Balb/c-Mice

AU - Roszkowski, W.

AU - Ko, H. L.

AU - Roszkowski, K.

AU - Ciborowski, P.

AU - Jeljaszewicz, J.

AU - Pulverer, G.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - The effects of a 7 days chemotherapy with ciprofloxacin on the humoral and cellular immune responses in Balb/c-mice were examined. Ciprofloxacin-doses used were calculated on a body weight basis from therapeutic dosages in humans. In a dose-dependent way IgM as well as IgG responses were significantly increased. The delayed-type hypersensitivity reaction to oxazolone was not significantly changed. In in vivo as well in vitro experiments ciprofloxacin showed no modulatory activity on the concanavalin A and LPS-induced proliferative activities of mouse spleen cells.

AB - The effects of a 7 days chemotherapy with ciprofloxacin on the humoral and cellular immune responses in Balb/c-mice were examined. Ciprofloxacin-doses used were calculated on a body weight basis from therapeutic dosages in humans. In a dose-dependent way IgM as well as IgG responses were significantly increased. The delayed-type hypersensitivity reaction to oxazolone was not significantly changed. In in vivo as well in vitro experiments ciprofloxacin showed no modulatory activity on the concanavalin A and LPS-induced proliferative activities of mouse spleen cells.

UR - http://www.scopus.com/inward/record.url?scp=0022976189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022976189&partnerID=8YFLogxK

U2 - 10.1016/S0176-6724(86)80013-X

DO - 10.1016/S0176-6724(86)80013-X

M3 - Article

C2 - 3788352

AN - SCOPUS:0022976189

VL - 262

SP - 396

EP - 402

JO - International Journal of Medical Microbiology

JF - International Journal of Medical Microbiology

SN - 1438-4221

IS - 3

ER -