Effects of calcium channel blockers on tardive dyskinesia

John L. Hendrickson, Cynthia R Ellis, Nirbhay N. Singh, Yadhu N. Singh, Robert W. Ricketts

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Tardive dyskinesia (TD) is a serious iatrogenic disorder that is induced by long-term neuroleptic therapy. There are no well-established treatments for TD but a number of agents, such as calcium channel blockers and vitamin E, have shown some promise in decreasing the symptoms of TD. We reviewed the treatment outcome literature on the efficacy of the three prototypic calcium channel blockers, verapamil, diltiazem, and nifedipine, on TD. Although the outcome data were equivocal, when taken in their best light, they suggested that calcium channel blockers may be effective in decreasing the symptoms of TD. However, the studies were methodologically flawed in many respects and future research must ensure that the basic requirements for scientific validity are incorporated in the experimental design. Further, there is a need for dose-response studies of the three prototypic calcium channel blockers, as well as investigations of their comparative effects.

Original languageEnglish (US)
Pages (from-to)125-136
Number of pages12
JournalJournal of Developmental and Physical Disabilities
Volume6
Issue number2
DOIs
StatePublished - Jun 1 1994

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Calcium Channel Blockers
Diltiazem
Nifedipine
Verapamil
Vitamin E
Design of experiments
Antipsychotic Agents
Research Design
Tardive Dyskinesia
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Keywords

  • Tardive dyskinesia
  • calcium channel blockers
  • neuroleptics

ASJC Scopus subject areas

  • Health Professions(all)
  • Clinical Biochemistry

Cite this

Effects of calcium channel blockers on tardive dyskinesia. / Hendrickson, John L.; Ellis, Cynthia R; Singh, Nirbhay N.; Singh, Yadhu N.; Ricketts, Robert W.

In: Journal of Developmental and Physical Disabilities, Vol. 6, No. 2, 01.06.1994, p. 125-136.

Research output: Contribution to journalArticle

Hendrickson, John L. ; Ellis, Cynthia R ; Singh, Nirbhay N. ; Singh, Yadhu N. ; Ricketts, Robert W. / Effects of calcium channel blockers on tardive dyskinesia. In: Journal of Developmental and Physical Disabilities. 1994 ; Vol. 6, No. 2. pp. 125-136.
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