Effects of Attenuation and Thrombus Age on the Success of Ultrasound and Microbubble-Mediated Thrombus Dissolution

Feng Xie, E. Carr Everbach, Shunji Gao, Lucas K. Drvol, William T. Shi, Francois Vignon, Jeff E. Powers, John Lof, Thomas Richard Porter

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The purpose of this study was to examine the effects of applied mechanical index, incident angle, attenuation and thrombus age on the ability of 2-D vs. 3-D diagnostic ultrasound and microbubbles to dissolve thrombi. A total of 180 occlusive porcine arterial thrombi of varying age (3 or 6 h) were examined in a flow system. A tissue-mimicking phantom of varying thickness (5 to 10 cm) was placed over the thrombosed vessel and the 2-D or 3-D diagnostic transducer aligned with the thrombosed vessel using a positioning system. Diluted lipid-encapsulated microbubbles were infused during ultrasound application. Percent thrombus dissolution (%TD) was calculated by comparison of clot mass before and after treatment. Both 2-D and 3-D-guided ultrasound increased %TD compared with microbubbles alone, but %TD achieved with 6-h-old thrombi was significantly less than 3-h-old thrombi. Thrombus dissolution was achieved at 10 cm tissue-mimicking depths, even without inertial cavitation. In conclusion, diagnostic 2-D or 3-D ultrasound can dissolve thrombi with intravenous nontargeted microbubbles, even at tissue attenuation distances of up to 10 cm. This treatment modality is less effective, however, for older aged thrombi.

Original languageEnglish (US)
Pages (from-to)280-288
Number of pages9
JournalUltrasound in Medicine and Biology
Volume37
Issue number2
DOIs
StatePublished - Feb 1 2011

Fingerprint

Microbubbles
dissolving
Thrombosis
attenuation
vessels
cavitation flow
positioning
lipids
transducers
Transducers
Ultrasonography
Swine

Keywords

  • Microbubbles
  • Three-dimensional ultrasound
  • Thrombus

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Cite this

Effects of Attenuation and Thrombus Age on the Success of Ultrasound and Microbubble-Mediated Thrombus Dissolution. / Xie, Feng; Everbach, E. Carr; Gao, Shunji; Drvol, Lucas K.; Shi, William T.; Vignon, Francois; Powers, Jeff E.; Lof, John; Porter, Thomas Richard.

In: Ultrasound in Medicine and Biology, Vol. 37, No. 2, 01.02.2011, p. 280-288.

Research output: Contribution to journalArticle

Xie, Feng ; Everbach, E. Carr ; Gao, Shunji ; Drvol, Lucas K. ; Shi, William T. ; Vignon, Francois ; Powers, Jeff E. ; Lof, John ; Porter, Thomas Richard. / Effects of Attenuation and Thrombus Age on the Success of Ultrasound and Microbubble-Mediated Thrombus Dissolution. In: Ultrasound in Medicine and Biology. 2011 ; Vol. 37, No. 2. pp. 280-288.
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