Effects of arginine-based supplements on the physical working capacity at the fatigue threshold

Clayton L. Camic, Terry J. Housh, Jorge M. Zuniga, Russell C. Hendrix, Michelle Mielke, Glen O. Johnson, Richard J. Schmidt

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The purpose of the present study was to examine the effects of daily oral administration of arginine-based supplements for 4 weeks on the physical working capacity at the fatigue threshold (PWCFT). The PWCFT test is an electromyographic (EMG) procedure for estimating the highest power output that can be maintained without neuromuscular evidence of fatigue. The study used a double-blind, placebo-controlled design. Fifty college-aged men (mean age ± SD = 23.9 ± 3.0) were randomized into 1 of 3 groups: (a) placebo (n = 19); (b) 1.5 g arginine (n = 14); or (c) 3.0 g arginine (n = 17). The placebo was microcrystalline cellulose. The 1.5-g arginine group ingested 1.5 g of arginine and 300 mg of grape seed extract, whereas the 3.0 g arginine group ingested 3.0 g of arginine and 300 mg of grape seed extract. All subjects performed an incremental test to exhaustion on a cycle ergometer to determine their PWCFT before supplementation (PRE) and after 4 weeks of supplementation (POST). Surface EMG signals were recorded from the vastus lateralis using a bipolar electrode arrangement during the incremental tests for the determination of the PRE and POST supplementation PWCFT values. There were significant mean increases (PRE to POST) in PWCFT for the 1.5 g (22.4%) and 3.0 g (18.8%) supplement groups, but no change for the placebo group (-1.6%). These findings supported the use of arginine-based supplements, at the dosages examined in the present investigation, as an ergogenic aid for untrained individuals.

Original languageEnglish (US)
Pages (from-to)1306-1312
Number of pages7
JournalJournal of strength and conditioning research
Volume24
Issue number5
DOIs
StatePublished - May 2010

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Fatigue
Arginine
Grape Seed Extract
Placebos
Quadriceps Muscle
Oral Administration
Electrodes

Keywords

  • Electromyographic amplitude
  • Grape seed extract
  • Neuromuscular
  • Supplementation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effects of arginine-based supplements on the physical working capacity at the fatigue threshold. / Camic, Clayton L.; Housh, Terry J.; Zuniga, Jorge M.; Hendrix, Russell C.; Mielke, Michelle; Johnson, Glen O.; Schmidt, Richard J.

In: Journal of strength and conditioning research, Vol. 24, No. 5, 05.2010, p. 1306-1312.

Research output: Contribution to journalArticle

Camic, Clayton L. ; Housh, Terry J. ; Zuniga, Jorge M. ; Hendrix, Russell C. ; Mielke, Michelle ; Johnson, Glen O. ; Schmidt, Richard J. / Effects of arginine-based supplements on the physical working capacity at the fatigue threshold. In: Journal of strength and conditioning research. 2010 ; Vol. 24, No. 5. pp. 1306-1312.
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