Effects of an orally administered live Escherichia coli pilus vaccine on duration of lacteal immunity to enterotoxigenic Escherichia coli in swine.

H. W. Moon, D. G. Rogers, R. Rose

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Primigravid swine were vaccinated orally with a live enterotoxigenic Escherichia coli (ETEC) strain that produces pilus antigen K99. The titers of K99 antibody in colostrum and milk of vaccinates remained higher than those of nonvaccinated controls through the first lactation after vaccination (4 weeks). Some control swine had low titers of K99 antibody in colostrum or developed low titers of K99 antibody in milk during lactation. Lacteal K99 antibody titers of vaccinates dropped to control levels during the second lactation, 6 months after vaccination. Pigs suckling vaccinates and controls were equally susceptible to challenge exposure to K99+ ETEC during the second lactation. Orally vaccinated swine given a parenteral booster vaccination (with killed K99+ ETEC) during their second gestation had K99 antibody in milk through their second lactation. During the second lactation, these orally vaccinated parenterally revaccinated swine had higher titers of K99 antibody in postcolostral milk than did nonvaccinated controls, controls given only the parenteral booster injection, or controls vaccinated parenterally during both gestations.

Original languageEnglish (US)
Pages (from-to)2068-2071
Number of pages4
JournalAmerican journal of veterinary research
Volume49
Issue number12
StatePublished - Dec 1988

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Escherichia coli Vaccines
Enterotoxigenic Escherichia coli
enterotoxigenic Escherichia coli
fimbriae
Lactation
Immunity
Milk
Swine
lactation
immunity
vaccines
Escherichia coli
milk
swine
antibodies
duration
Antibodies
Vaccination
Colostrum
colostrum

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effects of an orally administered live Escherichia coli pilus vaccine on duration of lacteal immunity to enterotoxigenic Escherichia coli in swine. / Moon, H. W.; Rogers, D. G.; Rose, R.

In: American journal of veterinary research, Vol. 49, No. 12, 12.1988, p. 2068-2071.

Research output: Contribution to journalArticle

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