Effects of a single intoxicating dose of ethanol on the vitamin profile of organelles in rat liver and brain

O. Frank, A. Luisada-Opper, Michael Floyd Sorrell, Rowen K Zetterman, H. Baker

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12 Citations (Scopus)

Abstract

The effects of a single, oral, intoxicating dose of ethanol (EtOH, 9g/kg body weight) on the distribution of water and fat soluble vitamins in various subcellular fractions of eight rat livers and eight rat brains was surveyed. Results were compared to eight other rats receiving a similar dose of saline (controls). Both organs showed redistribution of vitamins among the various organelles after EtOH was given. In saline treated animals the nucleus and cytosol of the liver contained the highest proportion of all vitamins and the microsomes and lysosomes contained the least. As compared to controls, EtOH ingestion generally caused the mitochondria and microsomes to accumulate vitamins, while vitamins in the lysosomes were decreased. A different pattern was seen in the brain after EtOH administration. Except for thiamine and niacin, the whole brain vitamins were higher than those in controls; they were primarily concentrated in the brain nucleus and mitochondria. It was concluded that changes in the organelle vitamin content of the liver were the result of EtOH injury. The simultaneous attempt to repair the injury was manifested by the sequestration of vitamins in the organelles of EtOH treated animals as compared to controls.

Original languageEnglish (US)
Pages (from-to)606-614
Number of pages9
JournalJournal of Nutrition
Volume106
Issue number5
StatePublished - Dec 1 1976

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Vitamins
Organelles
organelles
vitamins
Ethanol
ethanol
brain
liver
Liver
rats
Brain
dosage
microsomes
lysosomes
mitochondria
Microsomes
Lysosomes
water-soluble vitamins
fat soluble vitamins
vitamin content

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effects of a single intoxicating dose of ethanol on the vitamin profile of organelles in rat liver and brain. / Frank, O.; Luisada-Opper, A.; Sorrell, Michael Floyd; Zetterman, Rowen K; Baker, H.

In: Journal of Nutrition, Vol. 106, No. 5, 01.12.1976, p. 606-614.

Research output: Contribution to journalArticle

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