Effects of a hyperbaric environment on respiratory and monoamine oxidase activities

J. D. Geiger, S. J. Brumleve, J. N. Boelkins, S. S. Parmar

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Abstract

The effects of a prolonged hyperbaric environment (21 ATA He O2, 200 ± 30 mm Hg O2, 32.5 ± 1°C) were investigated on the respiratory activity of rat liver homogenates and the activity of monoamine oxidase in isolated rat liver preparations. Exposure to a hyperbaric environment for 84 days caused selective in vitro inhibition of nicotinamide adenine dinucleotide (NAD) dependent oxidation of pyruvate, D isocitrate, and α ketoglutarate by rat liver homogenates. The addition of NAD to the reaction mixture decreased the degree of such an inhibition. No effects on the in vitro activity of liver monoamine oxidase and its inhibition by pheniprazine were observed during exposure of animals to a prolonged high pressure environment.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
JournalUndersea Biomedical Research
Volume3
Issue number2
StatePublished - Dec 1 1976

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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