Effects of 8-epi-prostaglandin F2α and prostaglandin F2α on serum progesterone concentration and corpus luteum size in ewes

Dustin T Yates, L. J. Yates, D. M. Hallford, T. T. Ross

Research output: Contribution to journalArticle

Abstract

Prostaglandin F2α (PGF2α) is luteolytic in sheep. This study assessed luteolytic ability of an isomer, 8- epi-PGF2α. Ten ewes were estrus-synchronized and blood serum was collected for 12 days and analyzed for progesterone concentration. Ewes were laparoscopically administered 200 μg 8-epi-PGF2αor PGF2α, or placebo in each ovary on day 8 and ovariectomized on day 13. Corpora lutea (CL) were weighed. Serum progesterone was reduced (P < 0.041) by PGF2α on day 9, but recovered to control levels (P = 0.646) by day 10. Interestingly, 8-epi-PGF2α increased (P < 0.050) serum progesterone on days 9, 10, and 12. However, area under curve for serum progesterone between days 8 and 12 did not differ (P = 0.165) among treatments. In ewes administered PGF2α, serum progesterone decreased sharply (P < 0.001) after treatment, but recovered (P = 0.217) to pre treatment levels by day 11, indicating limited luteolysis after one-time dosage. Mean CL weight did not differ (P = 0.836) among treatments, but weight of largest CL was reduced by 8-epi-PGF2α (P = 0.032) and PGF2α (P = 0.015). One-time, intraovarian administration of 8-epi-PGF2α at this dosage did not cause luteolysis. Additionally, serum progesterone is capable of recovery from one-time, intra-ovarian administration of PGF2α.

Original languageEnglish (US)
Pages (from-to)1425-1429
Number of pages5
JournalAfrican Journal of Agricultural Research
Volume6
Issue number6
StatePublished - Mar 18 2011

Fingerprint

Dinoprost
Corpus Luteum
blood serum
corpus luteum
prostaglandins
Progesterone
ewes
progesterone
Serum
Luteolysis
luteolysis
Weights and Measures
Estrus
Therapeutics
dosage
placebos
Area Under Curve
isomers
estrus
Ovary

Keywords

  • 8-epi-prostaglandin F2α
  • Luteolysis
  • Prostaglandin F2α

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Effects of 8-epi-prostaglandin F2α and prostaglandin F2α on serum progesterone concentration and corpus luteum size in ewes. / Yates, Dustin T; Yates, L. J.; Hallford, D. M.; Ross, T. T.

In: African Journal of Agricultural Research, Vol. 6, No. 6, 18.03.2011, p. 1425-1429.

Research output: Contribution to journalArticle

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