Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats

Weihai Chen, Qi Zhang, Wenxin Su, Haorong Zhang, Yu Yang, Jing Qiao, Nan Sui, Ming Li

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Maternal behavior in rats is a highly motivated and well-organized social behavior. Given the known roles of serotonin (5-HT) in emotion, motivation, social behavior, and major depression - and its known interaction with dopamine - it is likely that serotonin also plays a crucial role in this behavior. So far, there are surprisingly few studies focusing on 5-HT in maternal behavior, except for maternal aggression. In the present study, we examined the effects of 5-HT2C receptor agonism and 5-HT2A receptor antagonism on maternal behavior in postpartum female rats. We hypothesized that activation of 5-HT2C receptors and blockade of 5-HT2A receptors would produce a functionally equivalent disruption of maternal behavior because these two receptor subtypes often exert opposite effects on various brain functions and psychological processes relevant to rat maternal behavior. On postpartum Days 5, 7, and 9, Sprague-Dawley mother rats were given a single injection of 0.9% NaCl solution, the 5-HT2C agonist MK212 (0.5, 1.0 or 2.0 mg/kg, ip), or the 5-HT2A antagonist MDL100907 (0.05, 0.5 or 2.0 mg/kg, ip). Maternal behavior was tested 30 min before and 30 min, 120 min, 240 min after injection. Acute injection of MK212 significantly disrupted pup retrieval, pup licking, pup nursing, and nest building in a dose-dependent fashion. At the tested doses, MDL100907 had little effect on various components of rat maternal behavior. Across the 3 days of testing, no apparent sensitization or tolerance associated with repeated administration of MK212 and MDL100907 was found. We concluded that rat maternal performance is critically dependent on 5-HT 2C receptors, while the role of 5-HT2A receptors is still inconclusive. Possible behavioral mechanisms of actions of 5-HT2C receptor in maternal behavior are discussed.

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalPharmacology Biochemistry and Behavior
Volume117
DOIs
StatePublished - Jan 1 2014

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Maternal Behavior
Serotonin Receptors
Receptor, Serotonin, 5-HT2C
Postpartum Period
Rats
Serotonin
Receptor, Serotonin, 5-HT2A
Social Behavior
Mothers
Serotonin 5-HT2 Receptor Agonists
Injections
Serotonin 5-HT2 Receptor Antagonists
Nursing
Dopamine
Brain
Chemical activation
Aggression
Sprague Dawley Rats
Motivation
Emotions

Keywords

  • 5-Hydroxytryptamine 2A receptor
  • 5-Hydroxytryptamine 2C receptor
  • MDL100907
  • MK212
  • Maternal behavior

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats. / Chen, Weihai; Zhang, Qi; Su, Wenxin; Zhang, Haorong; Yang, Yu; Qiao, Jing; Sui, Nan; Li, Ming.

In: Pharmacology Biochemistry and Behavior, Vol. 117, 01.01.2014, p. 25-33.

Research output: Contribution to journalArticle

Chen, Weihai ; Zhang, Qi ; Su, Wenxin ; Zhang, Haorong ; Yang, Yu ; Qiao, Jing ; Sui, Nan ; Li, Ming. / Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats. In: Pharmacology Biochemistry and Behavior. 2014 ; Vol. 117. pp. 25-33.
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AU - Sui, Nan

AU - Li, Ming

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