Effects of 2, 4, 5-trichlorophenoxyacetic acid, pentachlorophenol, methylprednisolone, and freund’s adjuvant on 2-hydroxyethylnitrosourea carcinogenesis in mrc-wistar rats

S. S. Mirvish, J. Nickols, D. D. Weisenburger, D. Johnson, Shantaram S Joshi, P. Kaplan, M. Gross, Y. Tong

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A link was proposed between human non-Hodgkin’s lymphoma and exposure to 2, 4, 5-trichlorophenoxyacetic acid (245T) and pentachlorophenol (PCP). To test this view and the hypothesis that immune suppression or stimulation could affect B-cell lymphoma (BCL) induction, we administered chronically to MRC-Wistar (MRC-W) rats of both sexes 98% pure 245T (600 mg/kg diet), 86% pure PCP (500 mg/kg diet), methyl- prednisolone (20 mg/kg ip weekly), and Freund’s adjuvant (0.5 ml im every 3-6 wk) for 40 wk, together with 75 mg 2-hydroxyethylnitrosourea (HENU)/I drinking water, a system known to induce B-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)59-74
Number of pages16
JournalJournal of Toxicology and Environmental Health
Volume32
Issue number1
DOIs
StatePublished - Jan 1991

Fingerprint

2,4,5-Trichlorophenoxyacetic Acid
Pentachlorophenol
Freund's Adjuvant
Methylprednisolone
B-Cell Lymphoma
Nutrition
Wistar Rats
Rats
Carcinogenesis
Cells
Diet
Acids
Prednisolone
Potable water
Drinking Water
Non-Hodgkin's Lymphoma

ASJC Scopus subject areas

  • Toxicology
  • Pollution

Cite this

Effects of 2, 4, 5-trichlorophenoxyacetic acid, pentachlorophenol, methylprednisolone, and freund’s adjuvant on 2-hydroxyethylnitrosourea carcinogenesis in mrc-wistar rats. / Mirvish, S. S.; Nickols, J.; Weisenburger, D. D.; Johnson, D.; Joshi, Shantaram S; Kaplan, P.; Gross, M.; Tong, Y.

In: Journal of Toxicology and Environmental Health, Vol. 32, No. 1, 01.1991, p. 59-74.

Research output: Contribution to journalArticle

@article{c6537dcbf4a647b38b0d3429a0b83e9a,
title = "Effects of 2, 4, 5-trichlorophenoxyacetic acid, pentachlorophenol, methylprednisolone, and freund’s adjuvant on 2-hydroxyethylnitrosourea carcinogenesis in mrc-wistar rats",
abstract = "A link was proposed between human non-Hodgkin’s lymphoma and exposure to 2, 4, 5-trichlorophenoxyacetic acid (245T) and pentachlorophenol (PCP). To test this view and the hypothesis that immune suppression or stimulation could affect B-cell lymphoma (BCL) induction, we administered chronically to MRC-Wistar (MRC-W) rats of both sexes 98{\%} pure 245T (600 mg/kg diet), 86{\%} pure PCP (500 mg/kg diet), methyl- prednisolone (20 mg/kg ip weekly), and Freund’s adjuvant (0.5 ml im every 3-6 wk) for 40 wk, together with 75 mg 2-hydroxyethylnitrosourea (HENU)/I drinking water, a system known to induce B-cell lymphoma.",
author = "Mirvish, {S. S.} and J. Nickols and Weisenburger, {D. D.} and D. Johnson and Joshi, {Shantaram S} and P. Kaplan and M. Gross and Y. Tong",
year = "1991",
month = "1",
doi = "10.1080/15287399109531465",
language = "English (US)",
volume = "32",
pages = "59--74",
journal = "Journal of Toxicology and Environmental Health",
issn = "0098-4108",
publisher = "Taylor and Francis Ltd.",
number = "1",

}

TY - JOUR

T1 - Effects of 2, 4, 5-trichlorophenoxyacetic acid, pentachlorophenol, methylprednisolone, and freund’s adjuvant on 2-hydroxyethylnitrosourea carcinogenesis in mrc-wistar rats

AU - Mirvish, S. S.

AU - Nickols, J.

AU - Weisenburger, D. D.

AU - Johnson, D.

AU - Joshi, Shantaram S

AU - Kaplan, P.

AU - Gross, M.

AU - Tong, Y.

PY - 1991/1

Y1 - 1991/1

N2 - A link was proposed between human non-Hodgkin’s lymphoma and exposure to 2, 4, 5-trichlorophenoxyacetic acid (245T) and pentachlorophenol (PCP). To test this view and the hypothesis that immune suppression or stimulation could affect B-cell lymphoma (BCL) induction, we administered chronically to MRC-Wistar (MRC-W) rats of both sexes 98% pure 245T (600 mg/kg diet), 86% pure PCP (500 mg/kg diet), methyl- prednisolone (20 mg/kg ip weekly), and Freund’s adjuvant (0.5 ml im every 3-6 wk) for 40 wk, together with 75 mg 2-hydroxyethylnitrosourea (HENU)/I drinking water, a system known to induce B-cell lymphoma.

AB - A link was proposed between human non-Hodgkin’s lymphoma and exposure to 2, 4, 5-trichlorophenoxyacetic acid (245T) and pentachlorophenol (PCP). To test this view and the hypothesis that immune suppression or stimulation could affect B-cell lymphoma (BCL) induction, we administered chronically to MRC-Wistar (MRC-W) rats of both sexes 98% pure 245T (600 mg/kg diet), 86% pure PCP (500 mg/kg diet), methyl- prednisolone (20 mg/kg ip weekly), and Freund’s adjuvant (0.5 ml im every 3-6 wk) for 40 wk, together with 75 mg 2-hydroxyethylnitrosourea (HENU)/I drinking water, a system known to induce B-cell lymphoma.

UR - http://www.scopus.com/inward/record.url?scp=0025980943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025980943&partnerID=8YFLogxK

U2 - 10.1080/15287399109531465

DO - 10.1080/15287399109531465

M3 - Article

C2 - 1987363

AN - SCOPUS:0025980943

VL - 32

SP - 59

EP - 74

JO - Journal of Toxicology and Environmental Health

JF - Journal of Toxicology and Environmental Health

SN - 0098-4108

IS - 1

ER -