Effects of 18-methoxycoronaridine on ghrelin-induced increases in sucrose intake and accumbal dopamine overflow in female rats

Sarah E. McCallum, Olga D. Taraschenko, Ethan R. Hathaway, Melanie Y. Vincent, Stanley D. Glick

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Rationale: 18-Methoxycoronaridine (18-MC), a selective antagonist of α3β4 nicotinic receptors, has been previously shown, in rats, to reduce the self-administration of several drugs of abuse, reduce operant responding for sucrose, and prevent the development of sucrose-induced obesity. It has become increasingly apparent that there is a significant overlap between the systems regulating drug reward and food intake, therefore, we investigated whether 18-MC might modulate the effects of ghrelin, one of several orexigenic peptides recently implicated in both feeding and drug reward. Objectives: In female Sprague-Dawley rats, we determined whether acute 18-MC treatment would reduce both ghrelin-induced increases in sucrose intake and ghrelin-elicited increases in accumbal dopamine levels. Results: Pretreatment with 18-MC (20 mg/kg, i.p.), given prior to the administration of ghrelin (1 μg, lateral ventricle), blocked ghrelin-induced increases in sucrose (5%) intake in a two-bottle open access paradigm. Using in vivo microdialysis, 18-MC (both 20 and 40 mg/kg) prevented ghrelin (2 μg, intraventral tegmental area)-induced increases in extracellular dopamine in the nucleus accumbens. 18-MC had no effect on deposition of fat or on serum levels of glucose, triglycerides, and cholesterol in ghrelin-treated rats. Conclusions: The present results suggest that one potential mechanism by which 18-MC exerts its effects on palatable food consumption is via modulation of ghrelin's effects.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalPsychopharmacology
Volume215
Issue number2
DOIs
StatePublished - May 1 2011

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Ghrelin
Sucrose
Dopamine
Reward
Self Administration
18-methoxycoronaridine
Lateral Ventricles
Microdialysis
Nucleus Accumbens
Nicotinic Receptors
Street Drugs
Pharmaceutical Preparations
Sprague Dawley Rats
Triglycerides
Obesity
Eating
Fats
Cholesterol
Glucose
Food

Keywords

  • 18-Methoxycoronaridine
  • Ghrelin
  • Nicotinic receptors
  • Obesity
  • Sucrose

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of 18-methoxycoronaridine on ghrelin-induced increases in sucrose intake and accumbal dopamine overflow in female rats. / McCallum, Sarah E.; Taraschenko, Olga D.; Hathaway, Ethan R.; Vincent, Melanie Y.; Glick, Stanley D.

In: Psychopharmacology, Vol. 215, No. 2, 01.05.2011, p. 247-256.

Research output: Contribution to journalArticle

McCallum, Sarah E. ; Taraschenko, Olga D. ; Hathaway, Ethan R. ; Vincent, Melanie Y. ; Glick, Stanley D. / Effects of 18-methoxycoronaridine on ghrelin-induced increases in sucrose intake and accumbal dopamine overflow in female rats. In: Psychopharmacology. 2011 ; Vol. 215, No. 2. pp. 247-256.
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