Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women

J. R. Stout, J. T. Cramer, R. F. Zoeller, D. Torok, P. Costa, J. R. Hoffman, R. C. Harris, J. O'Kroy

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

This study examined the effects of 28 days of β-alanine supplementation on the physical working capacity at fatigue threshold (PWC FT), ventilatory threshold (VT), maximal oxygen consumption (V̇O2-MAX), and time-to-exhaustion (TTE) in women. Twenty-two women (age ± SD 27.4 ± 6.1 yrs) participated and were randomly assigned to either the β-alanine (CarnoSyn™) or Placebo (PL) group. Before (pre) and after (post) the supplementation period, participants performed a continuous, incremental cycle ergometry test to exhaustion to determine the PWCFT, VT, V̇O2-MAX, and TTE. There was a 13.9, 12.6 and 2.5% increase (p < 0.05) in VT, PWCFT, and TTE, respectively, for the β-alanine group, with no changes in the PL (p > 0.05). There were no changes for V̇O2-MAX (p > 0.05) in either group. Results of this study indicate that β-alanine supplementation delays the onset of neuromuscular fatigue (PWCFT) and the ventilatory threshold (VT) at submaximal workloads, and increase in TTE during maximal cycle ergometry performance. However, β-alanine supplementation did not affect maximal aerobic power (V̇O2-MAX). In conclusion, β-alanine supplementation appears to improve submaximal cycle ergometry performance and TTE in young women, perhaps as a result of an increased buffering capacity due to elevated muscle carnosine concentrations.

Original languageEnglish (US)
Pages (from-to)381-386
Number of pages6
JournalAmino Acids
Volume32
Issue number3
DOIs
StatePublished - Apr 1 2007

Fingerprint

Alanine
Fatigue
Ergometry
Fatigue of materials
Carnosine
Workload
Oxygen Consumption
Muscle
Placebos
Oxygen
Muscles

Keywords

  • Carnosine
  • Cycle ergometry
  • Electromyography
  • Ergogenic aids
  • β-Alanine

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry
  • Endocrinology

Cite this

Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. / Stout, J. R.; Cramer, J. T.; Zoeller, R. F.; Torok, D.; Costa, P.; Hoffman, J. R.; Harris, R. C.; O'Kroy, J.

In: Amino Acids, Vol. 32, No. 3, 01.04.2007, p. 381-386.

Research output: Contribution to journalArticle

Stout, JR, Cramer, JT, Zoeller, RF, Torok, D, Costa, P, Hoffman, JR, Harris, RC & O'Kroy, J 2007, 'Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women', Amino Acids, vol. 32, no. 3, pp. 381-386. https://doi.org/10.1007/s00726-006-0474-z
Stout, J. R. ; Cramer, J. T. ; Zoeller, R. F. ; Torok, D. ; Costa, P. ; Hoffman, J. R. ; Harris, R. C. ; O'Kroy, J. / Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. In: Amino Acids. 2007 ; Vol. 32, No. 3. pp. 381-386.
@article{d3b2fda29f374a218b1fc9e92613b24e,
title = "Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women",
abstract = "This study examined the effects of 28 days of β-alanine supplementation on the physical working capacity at fatigue threshold (PWC FT), ventilatory threshold (VT), maximal oxygen consumption (V̇O2-MAX), and time-to-exhaustion (TTE) in women. Twenty-two women (age ± SD 27.4 ± 6.1 yrs) participated and were randomly assigned to either the β-alanine (CarnoSyn™) or Placebo (PL) group. Before (pre) and after (post) the supplementation period, participants performed a continuous, incremental cycle ergometry test to exhaustion to determine the PWCFT, VT, V̇O2-MAX, and TTE. There was a 13.9, 12.6 and 2.5{\%} increase (p < 0.05) in VT, PWCFT, and TTE, respectively, for the β-alanine group, with no changes in the PL (p > 0.05). There were no changes for V̇O2-MAX (p > 0.05) in either group. Results of this study indicate that β-alanine supplementation delays the onset of neuromuscular fatigue (PWCFT) and the ventilatory threshold (VT) at submaximal workloads, and increase in TTE during maximal cycle ergometry performance. However, β-alanine supplementation did not affect maximal aerobic power (V̇O2-MAX). In conclusion, β-alanine supplementation appears to improve submaximal cycle ergometry performance and TTE in young women, perhaps as a result of an increased buffering capacity due to elevated muscle carnosine concentrations.",
keywords = "Carnosine, Cycle ergometry, Electromyography, Ergogenic aids, β-Alanine",
author = "Stout, {J. R.} and Cramer, {J. T.} and Zoeller, {R. F.} and D. Torok and P. Costa and Hoffman, {J. R.} and Harris, {R. C.} and J. O'Kroy",
year = "2007",
month = "4",
day = "1",
doi = "10.1007/s00726-006-0474-z",
language = "English (US)",
volume = "32",
pages = "381--386",
journal = "Amino Acids",
issn = "0939-4451",
publisher = "Springer Wien",
number = "3",

}

TY - JOUR

T1 - Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women

AU - Stout, J. R.

AU - Cramer, J. T.

AU - Zoeller, R. F.

AU - Torok, D.

AU - Costa, P.

AU - Hoffman, J. R.

AU - Harris, R. C.

AU - O'Kroy, J.

PY - 2007/4/1

Y1 - 2007/4/1

N2 - This study examined the effects of 28 days of β-alanine supplementation on the physical working capacity at fatigue threshold (PWC FT), ventilatory threshold (VT), maximal oxygen consumption (V̇O2-MAX), and time-to-exhaustion (TTE) in women. Twenty-two women (age ± SD 27.4 ± 6.1 yrs) participated and were randomly assigned to either the β-alanine (CarnoSyn™) or Placebo (PL) group. Before (pre) and after (post) the supplementation period, participants performed a continuous, incremental cycle ergometry test to exhaustion to determine the PWCFT, VT, V̇O2-MAX, and TTE. There was a 13.9, 12.6 and 2.5% increase (p < 0.05) in VT, PWCFT, and TTE, respectively, for the β-alanine group, with no changes in the PL (p > 0.05). There were no changes for V̇O2-MAX (p > 0.05) in either group. Results of this study indicate that β-alanine supplementation delays the onset of neuromuscular fatigue (PWCFT) and the ventilatory threshold (VT) at submaximal workloads, and increase in TTE during maximal cycle ergometry performance. However, β-alanine supplementation did not affect maximal aerobic power (V̇O2-MAX). In conclusion, β-alanine supplementation appears to improve submaximal cycle ergometry performance and TTE in young women, perhaps as a result of an increased buffering capacity due to elevated muscle carnosine concentrations.

AB - This study examined the effects of 28 days of β-alanine supplementation on the physical working capacity at fatigue threshold (PWC FT), ventilatory threshold (VT), maximal oxygen consumption (V̇O2-MAX), and time-to-exhaustion (TTE) in women. Twenty-two women (age ± SD 27.4 ± 6.1 yrs) participated and were randomly assigned to either the β-alanine (CarnoSyn™) or Placebo (PL) group. Before (pre) and after (post) the supplementation period, participants performed a continuous, incremental cycle ergometry test to exhaustion to determine the PWCFT, VT, V̇O2-MAX, and TTE. There was a 13.9, 12.6 and 2.5% increase (p < 0.05) in VT, PWCFT, and TTE, respectively, for the β-alanine group, with no changes in the PL (p > 0.05). There were no changes for V̇O2-MAX (p > 0.05) in either group. Results of this study indicate that β-alanine supplementation delays the onset of neuromuscular fatigue (PWCFT) and the ventilatory threshold (VT) at submaximal workloads, and increase in TTE during maximal cycle ergometry performance. However, β-alanine supplementation did not affect maximal aerobic power (V̇O2-MAX). In conclusion, β-alanine supplementation appears to improve submaximal cycle ergometry performance and TTE in young women, perhaps as a result of an increased buffering capacity due to elevated muscle carnosine concentrations.

KW - Carnosine

KW - Cycle ergometry

KW - Electromyography

KW - Ergogenic aids

KW - β-Alanine

UR - http://www.scopus.com/inward/record.url?scp=34147124170&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34147124170&partnerID=8YFLogxK

U2 - 10.1007/s00726-006-0474-z

DO - 10.1007/s00726-006-0474-z

M3 - Article

C2 - 17136505

AN - SCOPUS:34147124170

VL - 32

SP - 381

EP - 386

JO - Amino Acids

JF - Amino Acids

SN - 0939-4451

IS - 3

ER -