Effectiveness of lipid microbubbles and ultrasound in declotting thrombosis

Feng Xie, Jeane M. Tsutsui, John Lof, Evan C. Unger, Jason M Johanning, William C. Culp, Terry Matsunaga, Thomas Richard Porter

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

The objectives of this study were to determine the effectiveness of lipid-encapsulated microbubbles and ultrasound (US) in recanalizing arteriovenous graft thrombi and the effect that tissue attenuation has on the success rate. A total of 55 thrombotic occlusions were created in four canines. The thrombosed grafts were randomly treated with two different 1-MHz US intensities, low (0.4 to 0.6 W/cm2) and high (10 W/cm2). Intragraft microbubbles were compared with intragraft saline and with the same dose of microbubbles given IV. IV microbubbles were also given both in the presence and absence of a tissue-mimicking phantom. High-intensity US (10 W/cm2) with intragraft microbubbles produced significantly higher patency and flow scores than did US with saline (p < 0.01). US with IV microbubbles had higher success rates in recanalizing thrombosed grafts than did US alone at all intensities. Attenuation reduced the rate at which successful recanalization occurred at both low and high intensities. US and microbubbles are capable of recanalizing acute arteriovenous graft thromboses. Higher intensities may be needed in the presence of tissue attenuation.

Original languageEnglish (US)
Pages (from-to)979-985
Number of pages7
JournalUltrasound in Medicine and Biology
Volume31
Issue number7
DOIs
StatePublished - Jul 1 2005

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thrombosis
Microbubbles
lipids
Thrombosis
Lipids
attenuation
Transplants
occlusion
dosage
Canidae

Keywords

  • Microbubbles
  • Thrombosis
  • Ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

Cite this

Effectiveness of lipid microbubbles and ultrasound in declotting thrombosis. / Xie, Feng; Tsutsui, Jeane M.; Lof, John; Unger, Evan C.; Johanning, Jason M; Culp, William C.; Matsunaga, Terry; Porter, Thomas Richard.

In: Ultrasound in Medicine and Biology, Vol. 31, No. 7, 01.07.2005, p. 979-985.

Research output: Contribution to journalArticle

Xie, Feng ; Tsutsui, Jeane M. ; Lof, John ; Unger, Evan C. ; Johanning, Jason M ; Culp, William C. ; Matsunaga, Terry ; Porter, Thomas Richard. / Effectiveness of lipid microbubbles and ultrasound in declotting thrombosis. In: Ultrasound in Medicine and Biology. 2005 ; Vol. 31, No. 7. pp. 979-985.
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