Effect of the anti‐estrogen, nafoxidine, on nzb/w autoimmune disease

Madeleine Duvic, Alfred D. Steinberg, Lynell Warren Klassen

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Treatment of female NZB/W F1 mice with Nafoxidine, an anti‐estrogen, led to delayed manifestation of autoimmune features. Such treated mice had reduced anti‐DNA antibodies, reduced proteinuria, and improved survival. These results support the hypothesis that sex hormones play an important role in the expression of autoimmunity and suggest that estrogens may accelerate autoimmunity in NZB/W F1 mice.

Original languageEnglish (US)
Pages (from-to)414-417
Number of pages4
JournalArthritis & Rheumatism
Volume21
Issue number4
DOIs
StatePublished - Jan 1 1978

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Nafoxidine
Estrogen Receptor Modulators
Autoimmune Diseases
Autoimmunity
Gonadal Steroid Hormones
Proteinuria
Estrogens
Antibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Effect of the anti‐estrogen, nafoxidine, on nzb/w autoimmune disease. / Duvic, Madeleine; Steinberg, Alfred D.; Klassen, Lynell Warren.

In: Arthritis & Rheumatism, Vol. 21, No. 4, 01.01.1978, p. 414-417.

Research output: Contribution to journalArticle

Duvic, Madeleine ; Steinberg, Alfred D. ; Klassen, Lynell Warren. / Effect of the anti‐estrogen, nafoxidine, on nzb/w autoimmune disease. In: Arthritis & Rheumatism. 1978 ; Vol. 21, No. 4. pp. 414-417.
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