Effect of sodium selenite upon bromobenzene toxicity in rats. I. Hepatotoxicity

B. Alex Merrick, Marc H. Davies, Royhei Hasegawa, Margaret K. St. John, Samuel Monroe Cohen, R. Craig Schnell

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Abstract

The effects of sodium selenite on bromobenzene hepatotoxicity were examined in male rats. Rats pretreated with sodium selenite (12.5 or 30 μmol/kg, ip) 72 hr prior to injection of bromobenzene (7.5 mmol/kg, ip) showed a marked reduction in bromobenzene-induced liver injury as evidenced by decreased plasma alanine and aspartate transaminase values, sorbitol dehydrogenase activity, and reduced histologic damage. Administration of bromobenzene did not affect the selenium content of blood or liver. At 72 hr after treatment with selenite, hepatic reduced (GSH) and oxidized (GSSG) glutathione values or GSH synthetic and degradation enzyme activities were not altered. However, from 3 to 12 hr following bromobenzene administration, hepatic GSH and cysteine amounts declined less rapidly in selenite-treated rats compared to control. Thus, acute selenite treatment ameliorated bromobenzene hepatotoxicity in a manner suggesting facilitation of hepatic GSH production by selenite for use in bromobenzene detoxication.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalToxicology and Applied Pharmacology
Volume83
Issue number2
DOIs
StatePublished - Jan 1 1986

Fingerprint

Sodium Selenite
Toxicity
Rats
Selenious Acid
Liver
Glutathione Disulfide
L-Iditol 2-Dehydrogenase
Enzyme activity
Selenium
Aspartate Aminotransferases
bromobenzene
Alanine Transaminase
Glutathione
Cysteine
Blood
Plasmas
Degradation
Injections
Wounds and Injuries
Enzymes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Effect of sodium selenite upon bromobenzene toxicity in rats. I. Hepatotoxicity. / Merrick, B. Alex; Davies, Marc H.; Hasegawa, Royhei; St. John, Margaret K.; Cohen, Samuel Monroe; Schnell, R. Craig.

In: Toxicology and Applied Pharmacology, Vol. 83, No. 2, 01.01.1986, p. 271-278.

Research output: Contribution to journalArticle

Merrick, B. Alex ; Davies, Marc H. ; Hasegawa, Royhei ; St. John, Margaret K. ; Cohen, Samuel Monroe ; Schnell, R. Craig. / Effect of sodium selenite upon bromobenzene toxicity in rats. I. Hepatotoxicity. In: Toxicology and Applied Pharmacology. 1986 ; Vol. 83, No. 2. pp. 271-278.
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