Effect of simvastatin injections on temporomandibular joint inflammation in growing rats

Mark D. George, Callista M. Owen, Adam L Reinhardt, Peter J Giannini, David B. Marx, Richard A Reinhardt

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: Juvenile idiopathic arthritis often affects the temporomandibular joint (TMJ), resulting in facial deformities, and intra-articular injections of anti-inflammatory steroids used in treatment may inhibit bone growth in the developing condyle. The purpose of this pilot study was to evaluate the anti-inflammatory properties of simvastatin (SIM), a bone anabolic drug, compared with the common steroid triamcinolone hexacetonide (TH) in experimental TMJ arthritis of growing rats. Methods: Joint inflammation was induced by injecting complete Freund's adjuvant (CFA) into the TMJs of 32 growing (4-week-old) Sprague-Dawley rats while simultaneously receiving 1) ethanol drug carrier, 2) 0.1 mg of SIM, 3) 0.5 mg of SIM, or 4) 0.15 mg of TH. Six rats had no treatment to the TMJ. Animals were euthanized 28 days later, and TMJs were decalcified and stained with hematoxylin-eosin. Results: Histopathologic TMJ results showed that CFA injection along with drug carrier induced increased thickness of the articular layer on the head of the condyle and inflammation of the retrodiscal area (CFA and ethanol). Although both TH and SIM reduced the articular layer thickness, 0.5 mg of SIM was more effective at reducing subsynovial inflammation. Conclusions: Intra-articular simvastatin showed anti-inflammatory properties in this TMJ model, prompting its further study in the growing TMJ, where bone anabolic properties would be important.

Original languageEnglish (US)
Pages (from-to)846-853
Number of pages8
JournalJournal of Oral and Maxillofacial Surgery
Volume71
Issue number5
DOIs
StatePublished - May 1 2013

Fingerprint

Simvastatin
Temporomandibular Joint
Inflammation
Injections
Freund's Adjuvant
Joints
Bone and Bones
Drug Carriers
Anti-Inflammatory Agents
Ethanol
Steroids
Intra-Articular Injections
Juvenile Arthritis
Bone Development
Hematoxylin
Eosine Yellowish-(YS)
Arthritis
Sprague Dawley Rats
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

Effect of simvastatin injections on temporomandibular joint inflammation in growing rats. / George, Mark D.; Owen, Callista M.; Reinhardt, Adam L; Giannini, Peter J; Marx, David B.; Reinhardt, Richard A.

In: Journal of Oral and Maxillofacial Surgery, Vol. 71, No. 5, 01.05.2013, p. 846-853.

Research output: Contribution to journalArticle

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