Effect of serum lipoproteins of bile obstructed rats on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in perfused rat liver

A. J. Barak, Michael Floyd Sorrell, D. J. Tuma

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Total lipoproteins as well as fractionated VLDL+LDL and HDL from fasted control rats and bileligated rats were tested in liver perfusion for their effect on 3-hydroxy-3-methylglutaryl CoA reductase to increase 3-hydroxy-3-methylglutaryl CoA reductase activity than that of the control total lipoproteins. When the fractionated lipoproteins were tested from fasted control rats, it was found that the major stimulating activity was in the HDL fraction with minor activity in the VLDL+LDL fraction. When these plasma components isolated from fasted bile-ligated rats were tested, it was found that the major activity had shifted to the VLDL+LDL fraction with the HDL having only a minor stimulatory role. The possible mechanism of action of the abnormal lipoproteins associated with bile obstruction in regulating 3-hydroxy-3-methylglutaryl CoA reductase activity is discussed.

Original languageEnglish (US)
Pages (from-to)883-887
Number of pages5
JournalLipids
Volume14
Issue number11
DOIs
StatePublished - Nov 1 1979

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Hydroxymethylglutaryl CoA Reductases
bile
Rat control
Bile
lipoproteins
Liver
Lipoproteins
Rats
Oxidoreductases
liver
rats
Serum
VLDL Lipoproteins
intestinal obstruction
Plasmas
mechanism of action
Perfusion
oxidized low density lipoprotein
3-hydroxy-3-methylglutaryl-coenzyme A
hydroxymethylglutaryl-CoA reductases

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

Cite this

Effect of serum lipoproteins of bile obstructed rats on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in perfused rat liver. / Barak, A. J.; Sorrell, Michael Floyd; Tuma, D. J.

In: Lipids, Vol. 14, No. 11, 01.11.1979, p. 883-887.

Research output: Contribution to journalArticle

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