Effect of renal denervation on arterial pressure in rats with aortic nerve transection

R. L. Kline, K. P. Patel, J. Ciriello, P. F. Mercer

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The role of renal nerves in influencing the control of arterial pressure was studied in Wistar rats with aortic depressor nerve (ADN) transection. Renal denervation prevented or reversed the normal increase in arterial pressure seen after ADN transection. This effect was not due to an effect on the renin-angiotensin system, as the elevated arterial pressure after ADN section in rats with renal nerves intact was shown to be due to increased α-adrenergic activity. Food and water intake and urine output decreased significantly in both renal-denervated and sham-denervated rats after ADN section, suggesting that a pressure diuresis mechanism was not responsible for preventing the rise in pressure in renal-denervated rats. In another study, the concentration of norepinephrine in skeletal muscle and hypothalamus at 0 and 8 hours after inhibition of tyrosine hydroxylase with α-methyltyrosine was used as an index of norepinephrine turnover. Norepinephrine turnover in skeletal muscle was increased significantly over control values by ADN transection in sham renal-denervated rats, but was not significantly different from controls in renal-denervated rats with ADN section. In the hypothalamus, there was a significant difference between the turnover of norepinephrine in the two groups of ADN-sectioned rats. The results taken together suggest that renal denervation prevents the arterial pressure response to ADN transection by altering the central mechanisms governing sympathetic outflow. It is suggested that this effect may be due to elimination of information carried by afferent renal fibers.

Original languageEnglish (US)
Pages (from-to)468-475
Number of pages8
JournalHypertension
Volume5
Issue number4
DOIs
StatePublished - Jan 1 1983

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Denervation
Arterial Pressure
Kidney
Norepinephrine
Hypothalamus
Methyltyrosines
Skeletal Muscle
Pressure
Diuresis
Tyrosine 3-Monooxygenase
Renin-Angiotensin System
Adrenergic Agents
Drinking
Wistar Rats
Eating
Urine

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Effect of renal denervation on arterial pressure in rats with aortic nerve transection. / Kline, R. L.; Patel, K. P.; Ciriello, J.; Mercer, P. F.

In: Hypertension, Vol. 5, No. 4, 01.01.1983, p. 468-475.

Research output: Contribution to journalArticle

Kline, R. L. ; Patel, K. P. ; Ciriello, J. ; Mercer, P. F. / Effect of renal denervation on arterial pressure in rats with aortic nerve transection. In: Hypertension. 1983 ; Vol. 5, No. 4. pp. 468-475.
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