Effect of postoperative morbidity on long-term survival after hepatic resection for metastatic colorectal cancer

Hiromichi Ito, Chandrakanth Are, Mithat Gonen, Michael D'Angelica, Ronald P. DeMatteo, Nancy E. Kemeny, Yuman Fong, Leslie H. Blumgart, William R. Jarnagin

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Abstract

PURPOSE: Resection is the most effective treatment for metastatic colorectal cancer (MCRC) to the liver. However, postoperative morbidity is common and its impact on long-term oncological outcome is unclear. The objective of this study was to evaluate the impact of postoperative morbidity on the long-term outcome after liver resection for MCRC. METHODS: Medical records of patients who underwent liver resection for MCRC with curative intent between 1991 and 2002 were reviewed. Patients who died of postoperative complications were excluded; operative and perioperative data, including morbidity and clinicopathological variables, were analyzed. Patients were stratified by disease extent and risk of recurrence using a clinical risk scoring system. RESULTS: A total of 1067 patients were included in the study and the median follow-up period was 41 months. The overall morbidity rate was 42%; the 5-year disease-specific survival (DSS) and overall disease-free survival (DFS) rates of patients who had complications were 41% and 25%, respectively, compared with 48% and 33%, respectively, for patients who did not have complications (P = 0.0059 for DSS, P = 0.0053 for DFS). On multivariate analysis, morbidity was not an independent predictor of either DSS or DFS; however, in a subgroup of patients with low clinical risk scores, morbidity was associated with a significant reduction in both DSS and DFS. CONCLUSIONS: Postoperative morbidity adversely affects long-term outcome after hepatic resection for MCRC in patients at lower risk for recurrence. Efforts aimed at reducing perioperative morbidity will not only reduce usage of resources but will likely further enhance the therapeutic benefit of resection for such patients.

Original languageEnglish (US)
Pages (from-to)994-1002
Number of pages9
JournalAnnals of surgery
Volume247
Issue number6
DOIs
StatePublished - Jun 1 2008

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Colorectal Neoplasms
Morbidity
Survival
Liver
Disease-Free Survival
Recurrence
Liver Neoplasms
Medical Records
Multivariate Analysis
Survival Rate
Therapeutics

ASJC Scopus subject areas

  • Surgery

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Effect of postoperative morbidity on long-term survival after hepatic resection for metastatic colorectal cancer. / Ito, Hiromichi; Are, Chandrakanth; Gonen, Mithat; D'Angelica, Michael; DeMatteo, Ronald P.; Kemeny, Nancy E.; Fong, Yuman; Blumgart, Leslie H.; Jarnagin, William R.

In: Annals of surgery, Vol. 247, No. 6, 01.06.2008, p. 994-1002.

Research output: Contribution to journalArticle

Ito, H, Are, C, Gonen, M, D'Angelica, M, DeMatteo, RP, Kemeny, NE, Fong, Y, Blumgart, LH & Jarnagin, WR 2008, 'Effect of postoperative morbidity on long-term survival after hepatic resection for metastatic colorectal cancer', Annals of surgery, vol. 247, no. 6, pp. 994-1002. https://doi.org/10.1097/SLA.0b013e31816c405f
Ito, Hiromichi ; Are, Chandrakanth ; Gonen, Mithat ; D'Angelica, Michael ; DeMatteo, Ronald P. ; Kemeny, Nancy E. ; Fong, Yuman ; Blumgart, Leslie H. ; Jarnagin, William R. / Effect of postoperative morbidity on long-term survival after hepatic resection for metastatic colorectal cancer. In: Annals of surgery. 2008 ; Vol. 247, No. 6. pp. 994-1002.
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abstract = "PURPOSE: Resection is the most effective treatment for metastatic colorectal cancer (MCRC) to the liver. However, postoperative morbidity is common and its impact on long-term oncological outcome is unclear. The objective of this study was to evaluate the impact of postoperative morbidity on the long-term outcome after liver resection for MCRC. METHODS: Medical records of patients who underwent liver resection for MCRC with curative intent between 1991 and 2002 were reviewed. Patients who died of postoperative complications were excluded; operative and perioperative data, including morbidity and clinicopathological variables, were analyzed. Patients were stratified by disease extent and risk of recurrence using a clinical risk scoring system. RESULTS: A total of 1067 patients were included in the study and the median follow-up period was 41 months. The overall morbidity rate was 42{\%}; the 5-year disease-specific survival (DSS) and overall disease-free survival (DFS) rates of patients who had complications were 41{\%} and 25{\%}, respectively, compared with 48{\%} and 33{\%}, respectively, for patients who did not have complications (P = 0.0059 for DSS, P = 0.0053 for DFS). On multivariate analysis, morbidity was not an independent predictor of either DSS or DFS; however, in a subgroup of patients with low clinical risk scores, morbidity was associated with a significant reduction in both DSS and DFS. CONCLUSIONS: Postoperative morbidity adversely affects long-term outcome after hepatic resection for MCRC in patients at lower risk for recurrence. Efforts aimed at reducing perioperative morbidity will not only reduce usage of resources but will likely further enhance the therapeutic benefit of resection for such patients.",
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T1 - Effect of postoperative morbidity on long-term survival after hepatic resection for metastatic colorectal cancer

AU - Ito, Hiromichi

AU - Are, Chandrakanth

AU - Gonen, Mithat

AU - D'Angelica, Michael

AU - DeMatteo, Ronald P.

AU - Kemeny, Nancy E.

AU - Fong, Yuman

AU - Blumgart, Leslie H.

AU - Jarnagin, William R.

PY - 2008/6/1

Y1 - 2008/6/1

N2 - PURPOSE: Resection is the most effective treatment for metastatic colorectal cancer (MCRC) to the liver. However, postoperative morbidity is common and its impact on long-term oncological outcome is unclear. The objective of this study was to evaluate the impact of postoperative morbidity on the long-term outcome after liver resection for MCRC. METHODS: Medical records of patients who underwent liver resection for MCRC with curative intent between 1991 and 2002 were reviewed. Patients who died of postoperative complications were excluded; operative and perioperative data, including morbidity and clinicopathological variables, were analyzed. Patients were stratified by disease extent and risk of recurrence using a clinical risk scoring system. RESULTS: A total of 1067 patients were included in the study and the median follow-up period was 41 months. The overall morbidity rate was 42%; the 5-year disease-specific survival (DSS) and overall disease-free survival (DFS) rates of patients who had complications were 41% and 25%, respectively, compared with 48% and 33%, respectively, for patients who did not have complications (P = 0.0059 for DSS, P = 0.0053 for DFS). On multivariate analysis, morbidity was not an independent predictor of either DSS or DFS; however, in a subgroup of patients with low clinical risk scores, morbidity was associated with a significant reduction in both DSS and DFS. CONCLUSIONS: Postoperative morbidity adversely affects long-term outcome after hepatic resection for MCRC in patients at lower risk for recurrence. Efforts aimed at reducing perioperative morbidity will not only reduce usage of resources but will likely further enhance the therapeutic benefit of resection for such patients.

AB - PURPOSE: Resection is the most effective treatment for metastatic colorectal cancer (MCRC) to the liver. However, postoperative morbidity is common and its impact on long-term oncological outcome is unclear. The objective of this study was to evaluate the impact of postoperative morbidity on the long-term outcome after liver resection for MCRC. METHODS: Medical records of patients who underwent liver resection for MCRC with curative intent between 1991 and 2002 were reviewed. Patients who died of postoperative complications were excluded; operative and perioperative data, including morbidity and clinicopathological variables, were analyzed. Patients were stratified by disease extent and risk of recurrence using a clinical risk scoring system. RESULTS: A total of 1067 patients were included in the study and the median follow-up period was 41 months. The overall morbidity rate was 42%; the 5-year disease-specific survival (DSS) and overall disease-free survival (DFS) rates of patients who had complications were 41% and 25%, respectively, compared with 48% and 33%, respectively, for patients who did not have complications (P = 0.0059 for DSS, P = 0.0053 for DFS). On multivariate analysis, morbidity was not an independent predictor of either DSS or DFS; however, in a subgroup of patients with low clinical risk scores, morbidity was associated with a significant reduction in both DSS and DFS. CONCLUSIONS: Postoperative morbidity adversely affects long-term outcome after hepatic resection for MCRC in patients at lower risk for recurrence. Efforts aimed at reducing perioperative morbidity will not only reduce usage of resources but will likely further enhance the therapeutic benefit of resection for such patients.

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