Effect of phenobarbital on lipid peroxidation in the liver

Henry K J Hahn, Dean J. Tuma, Anthony J. Barak, Michael Floyd Sorrell

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

It has been established that the administration of phenobarbital to rats produces an accumulation of triglyceride in the liver. In the present study, it has been demonstrated that phenobarbital increases hepatic lipid peroxidation as reflected by the observed diene conjugation absorption of microsomal lipids as well as the increase in malonic dialdehyde formation. Both the fatty infiltration and the lipoperoxidation were found to be inhibited by an antioxidant. N, N′-diphenyl-p-phenylenediamine. These data suggest that the peroxidative process may play a role in the phenobarbital-induced fatty liver.

Original languageEnglish (US)
Pages (from-to)769-772
Number of pages4
JournalBiochemical Pharmacology
Volume25
Issue number7
DOIs
StatePublished - Apr 1 1976

Fingerprint

Phenobarbital
Liver
Lipid Peroxidation
Lipids
Fatty Liver
Infiltration
Rats
Triglycerides
Antioxidants

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

Cite this

Effect of phenobarbital on lipid peroxidation in the liver. / Hahn, Henry K J; Tuma, Dean J.; Barak, Anthony J.; Sorrell, Michael Floyd.

In: Biochemical Pharmacology, Vol. 25, No. 7, 01.04.1976, p. 769-772.

Research output: Contribution to journalArticle

Hahn, Henry K J ; Tuma, Dean J. ; Barak, Anthony J. ; Sorrell, Michael Floyd. / Effect of phenobarbital on lipid peroxidation in the liver. In: Biochemical Pharmacology. 1976 ; Vol. 25, No. 7. pp. 769-772.
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