Effect of oltipraz on hepatic glutathione content and metabolism, DNA damage and lipid peroxidation in mice as a function of age

S. J. Stohs, Terence A Lawson, L. Anderson, E. Bueding

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Female mice between the ages of 1-18 months were treated with 50 mg oltipraz/kg by intragastric tube every other day for 5 doses. At all ages, oltipraz resulted in significant increases in hepatic glutathione content and glutathione reductase and glutathione S-transferase activities. Oltipraz also produced decreases in hepatic DNA damage (single strand breaks) and lipid peroxidation (malondialdehyde content). Highest hepatic glutathione content and glutathione reductase and glutathione S-transferase activities occurred in mice approximately 9 months of age, and declined thereafter. Oltipraz administration to 18 month old mice increased glutathione content and glutathione S-transferase activity approximately to the levels observed in 9 month old mice. Oltipraz may be effective in retarding the free radical reaction processes associated with aging and cancer.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalAGE
Volume9
Issue number3
DOIs
StatePublished - Jul 1 1986

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Lipid Peroxidation
DNA Damage
Glutathione
Glutathione Transferase
Liver
Glutathione Reductase
Malondialdehyde
Free Radicals
oltipraz
Neoplasms

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Effect of oltipraz on hepatic glutathione content and metabolism, DNA damage and lipid peroxidation in mice as a function of age. / Stohs, S. J.; Lawson, Terence A; Anderson, L.; Bueding, E.

In: AGE, Vol. 9, No. 3, 01.07.1986, p. 65-69.

Research output: Contribution to journalArticle

Stohs, S. J. ; Lawson, Terence A ; Anderson, L. ; Bueding, E. / Effect of oltipraz on hepatic glutathione content and metabolism, DNA damage and lipid peroxidation in mice as a function of age. In: AGE. 1986 ; Vol. 9, No. 3. pp. 65-69.
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