Effect of nickel sulfate on cellular proliferation and Epstein-Barr virus antigen expression in lymphoblastoid cell lines

Yintang Wu, Hueiling Luo, Donald R Johnson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Nickel is found in high levels in the environment of the high-risk areas for nasopharyngeal carcinoma (NPC) of China. Epstein-Barr virus (EBV) is associated with NPC and the interaction of nickel and EBV may be a contributive cofactor to the development of NPC. The study of the in vitro effect of nickel sulfate on cell proliferation and EBV-antigen expression demonstrated that nickel increases cell proliferation of some EBV-positive lymphoblastoid cell lines and increases early antigen expression of Raji cells. Nickel exerted variable effects on viral capsid antigen (VCA): increasing VCA-positive cells in B95-8 cells while decreasing VCA in P3HR-1 cells. It is proposed that the uptake of nickel in NPC high-risk areas could be one of the factors responsible for cancer development in the nasopharynx in China.

Original languageEnglish (US)
Pages (from-to)171-179
Number of pages9
JournalCancer Letters
Volume32
Issue number2
DOIs
StatePublished - Jan 1 1986

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Nickel
Human Herpesvirus 4
Cell Proliferation
Viral Antigens
Capsid
Antigens
Cell Line
China
Nasopharynx
nickel sulfate
Nasopharyngeal carcinoma
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Effect of nickel sulfate on cellular proliferation and Epstein-Barr virus antigen expression in lymphoblastoid cell lines. / Wu, Yintang; Luo, Hueiling; Johnson, Donald R.

In: Cancer Letters, Vol. 32, No. 2, 01.01.1986, p. 171-179.

Research output: Contribution to journalArticle

Wu, Yintang ; Luo, Hueiling ; Johnson, Donald R. / Effect of nickel sulfate on cellular proliferation and Epstein-Barr virus antigen expression in lymphoblastoid cell lines. In: Cancer Letters. 1986 ; Vol. 32, No. 2. pp. 171-179.
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