Effect of Low Doses of Methamphetamine on Rat Limbic-Related Neurotensin Systems

Mario E. Alburges, Amanda J. Hoonakker, Nathaniel M. Cordova, Christina M. Robson, Lisa McFadden, Amber L. Martin, Glen R. Hanson

Research output: Contribution to journalArticle

Abstract

Administration of methamphetamine (METH) alters limbic-related (LR) neurotensin (NT) systems. Thus, through a D1-receptor mechanism, noncontingent high doses (5-15 mg kg-1), and likely self-administration, of METH appears to reduce NT release causing its accumulation and an elevation of NT-like immunoreactivity (NTLI) in limbic-related NT pathways. For comparison, we tested the effect of low doses of METH, that are more like those used in therapy, on NTLI in the core and shell of the nucleus accumbens (NAc and NAs), prefrontal cortex (PFC), ventral tegmental area (VTA), the lateral habenula (Hb) and basolateral amygdala (Amyg). METH at the dose of 0.25 mg kg-1 in particular, but not 1.00 mg kg-1, decreased NTLI concentration in all of the LR structures studied, except for the prefrontal cortex; however, these effects were rapid and brief being observed at 5 h but not at 24 h after treatment. In all of the LR areas where NTLI levels were reduced after the low dose of METH, the effect was blocked by pretreatment with either a D1 or a D2 antagonist. Thus, opposite to high doses like those associated with abuse, the therapeutic-like low-dose METH treatment induced reduction in NT tissue levels likely reflected an increase in NT release and a short-term depletion of the levels of this neuropeptide in LR structures, manifesting features comparable to the response of basal ganglia NT systems to similar low doses of METH.

Original languageEnglish (US)
Pages (from-to)396-404
Number of pages9
JournalSynapse
Volume69
Issue number8
DOIs
StatePublished - Aug 1 2015

Fingerprint

Neurotensin
Methamphetamine
Prefrontal Cortex
Habenula
Ventral Tegmental Area
Self Administration
Nucleus Accumbens
Therapeutics
Basal Ganglia
Neuropeptides

Keywords

  • Basal ganglia
  • Dopamine antagonists
  • Methamphetamine
  • Neurotensin
  • Stimulant

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Alburges, M. E., Hoonakker, A. J., Cordova, N. M., Robson, C. M., McFadden, L., Martin, A. L., & Hanson, G. R. (2015). Effect of Low Doses of Methamphetamine on Rat Limbic-Related Neurotensin Systems. Synapse, 69(8), 396-404. https://doi.org/10.1002/syn.21829

Effect of Low Doses of Methamphetamine on Rat Limbic-Related Neurotensin Systems. / Alburges, Mario E.; Hoonakker, Amanda J.; Cordova, Nathaniel M.; Robson, Christina M.; McFadden, Lisa; Martin, Amber L.; Hanson, Glen R.

In: Synapse, Vol. 69, No. 8, 01.08.2015, p. 396-404.

Research output: Contribution to journalArticle

Alburges, ME, Hoonakker, AJ, Cordova, NM, Robson, CM, McFadden, L, Martin, AL & Hanson, GR 2015, 'Effect of Low Doses of Methamphetamine on Rat Limbic-Related Neurotensin Systems', Synapse, vol. 69, no. 8, pp. 396-404. https://doi.org/10.1002/syn.21829
Alburges ME, Hoonakker AJ, Cordova NM, Robson CM, McFadden L, Martin AL et al. Effect of Low Doses of Methamphetamine on Rat Limbic-Related Neurotensin Systems. Synapse. 2015 Aug 1;69(8):396-404. https://doi.org/10.1002/syn.21829
Alburges, Mario E. ; Hoonakker, Amanda J. ; Cordova, Nathaniel M. ; Robson, Christina M. ; McFadden, Lisa ; Martin, Amber L. ; Hanson, Glen R. / Effect of Low Doses of Methamphetamine on Rat Limbic-Related Neurotensin Systems. In: Synapse. 2015 ; Vol. 69, No. 8. pp. 396-404.
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